PMID: 8959029Oct 31, 1996Paper

Hypersensitivity of nucleus accumbens neurons to methamphetamine and dopamine following repeated administrations of methamphetamine

Annals of the New York Academy of Sciences
Taku AmanoMasashi Sasa

Abstract

Methamphetamine (MAP) abuse is known to induce reverse tolerance in humans. Electrophysiological studies were performed to elucidate time-related changes in dopamine (DA) receptor sensitivities to DA and MAP after withdrawal following repeated MAP administrations. MAP (5 mg/kg) or physiological saline (1 ml/kg) was injected i.p. to rats once daily for 5 days. Single neuronal activities of nucleus accumbens (Acc) of 5-day MAP-administrated rats were extracellularly recorded with a glass microelectrode attached along a seven-barreled micropipette under chloral hydrate anesthesia. Each barrel was respectively filled with DA, MAP, haloperidol, glutamate and NaCl. Drugs were microiontophoretically applied to the immediate vicinity of Acc neurons receiving inputs from the parafascicular nucleus (Pf) of thalamus. Spikes elicited by Pf stimulation- and glutamate-induced firing were inhibited by iontophoretic application of either DA or MAP at doses of 20-40 nA in the saline-treated rats: EC50 for DA and MAP were 23.8 and 23.2 nA, respectively. At 24-30 hr after the final MAP administration, however, the inhibitory effects of both DA and MAP on Pf stimulation- and glutamate-induced firing of Acc neurons were less pronounced than those i...Continue Reading

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Citations

Jul 6, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kathleen M GrantRick A Bevins
Jan 6, 2005·Developmental Psychobiology·Romana SlamberováMarie Pometlová
Apr 6, 2005·Reproductive Toxicology·Romana SlamberováMarie Pometlová
Sep 6, 2005·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Taku AmanoNorio Sakai

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