Hypersensitivity of pulmonary C fibers induced by adenosine in anesthetized rats

Journal of Applied Physiology
Qihai GuLu-Yuan Lee

Abstract

Compelling clinical evidence implicates the potential role of adenosine in development of airway hyperresponsiveness and suggests involvement of pulmonary sensory receptors. This study was carried out to determine the effect of a low dose of adenosine infusion on sensitivity of pulmonary C-fiber afferents in anesthetized open-chest rats. Infusion of adenosine (40 microg x kg-1x min-1 i.v. for 90 s) mildly elevated baseline activity of pulmonary C fibers. However, during adenosine infusion, pulmonary C-fiber responses to chemical stimulants and lung inflation (30 cmH2O tracheal pressure) were markedly potentiated; e.g., the response to right atrial injection of capsaicin (0.25 or 0.5 microg/kg) was increased by more than fivefold (change in fiber activity = 2.64 +/- 0.67 and 16.27 +/- 3.11 impulses/s at control and during adenosine infusion, n = 13, P < 0.05), and this enhanced response returned to control in approximately 10 min. The potentiating effect of adenosine infusion was completely blocked by pretreatment with 8-cyclopentyl-1,3-dipropylxanthine (100 microg/kg), a selective antagonist of the adenosine A1 receptor, but was not affected by 3,7-dimethyl-1-propargylxanthine (1 mg/kg), an A2-receptor antagonist, or 3-ethyl-5-...Continue Reading

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Q Y ZhouO Civelli
Jun 1, 1992·The American Journal of Medicine·A C RankinB A McGovern
Dec 1, 1991·Journal of Applied Physiology·J Solway, A R Leff
Feb 7, 1992·Journal of Medicinal Chemistry·K A JacobsonM Williams
Jan 1, 1990·Annals of the New York Academy of Sciences·R F Bruns
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P PennefatherR A Nicoll
Jul 1, 1989·Progress in Cardiovascular Diseases·L BelardinelliR M Berne
Jan 1, 1987·Annual Review of Physiology·J M Lundberg, A Saria
Aug 1, 1987·The American Review of Respiratory Disease·R A Pauwels, M E Van der Straeten
Jan 1, 1973·Physiological Reviews·A S Paintal
Jan 1, 1984·Reviews of Physiology, Biochemistry and Pharmacology·J C Coleridge, H M Coleridge
Jan 1, 1995·The Journal of Physiology·H RajA S Paintal
Feb 1, 1994·Journal of the American College of Cardiology·M D CerqueiraA S Iskandrian
Jul 1, 1993·The American Review of Respiratory Disease·A G DriverS J Mustafa
Jul 1, 1993·Respiration Physiology·L Y Lee, R F Morton
May 1, 1993·The American Journal of Emergency Medicine·K K Burkhart
Feb 20, 1997·Nature·P J Richardson
Feb 20, 1997·Nature·J W Nyce, W J Metzger
Mar 5, 1998·The American Journal of Physiology·H R MiddlekauffJ N Weiss
Jul 4, 1998·Trends in Pharmacological Sciences·K A Jacobson
Aug 12, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P Forsythe, M Ennis
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·C Y HoL Y Lee
Mar 10, 2001·Respiration Physiology·L Y Lee, T E Pisarri
Jul 9, 2002·Pulmonary Pharmacology & Therapeutics·Lu-Yuan LeeQihai Gu
Sep 18, 2002·Journal of Applied Physiology·Kevin Kwong, Lu-Yuan Lee

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Citations

Jul 5, 2005·Journal of Applied Physiology·Ruei-Lung LinLu-Yuan Lee
Apr 1, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher R DesesaJohn B Morris
Nov 20, 2012·Chemical Senses·Daniel N Willis, John B Morris
Jun 24, 2006·The Journal of Physiology·Benjamas ChuaychooBradley J Undem
Nov 6, 2010·Chest·Nausherwan K Burki, Lu-Yuan Lee
Sep 16, 2009·Autonomic Neuroscience : Basic & Clinical·M KollarikM Brozmanova
Oct 24, 2007·Respiratory Physiology & Neurobiology·Mehdi S HazariDaniel L Costa
Feb 27, 2007·Respiratory Physiology & Neurobiology·S E McGowan
Mar 1, 2012·Experimental Physiology·Valdo Jose Dias da SilvaNicola Montano
Mar 31, 2007·Cell Death and Differentiation·B B Fredholm
Jul 15, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ryan P VaughanJohn B Morris
May 1, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiaoyang HuaStephen L Tilley
Aug 14, 2012·Pharmacological Reviews·Geoffrey BurnstockJean-Pierre Timmermans
Jun 10, 2016·Physiological Reviews·Stuart B Mazzone, Bradley J Undem
Jun 7, 2008·Journal of Applied Physiology·Y L Kuo, C J Lai
Jan 16, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ruei-Lung LinLu-Yuan Lee
Feb 22, 2014·Journal of Applied Physiology·I-Lun Tsai, Kun-Ze Lee
Oct 19, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mei-Ya ShenChing Jung Lai
Jul 21, 2021·Pharmacological Reports : PR·Mohammed Ahmed AkkaifBaharudin Ibrahim

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