Hypersensitivity pneumonitis induced by Shiitake mushroom spores

Medical Mycology
Alexandre AmpereBenoit Wallaert

Abstract

Hypersensitivity pneumonitis (HP) is a pulmonary granulomatosis involving an immunoallergic mechanism caused by chronic inhalation of antigens, most frequently organic substances, as well as chemicals. We report the first European case of hypersensitivity pneumonitis due to the inhalation of Shiitake mushroom spores. A 37-year-old French Caucasian man with a one-month history of persistent dry cough, shortness of breath and loss of weight was admitted to our hospital on December 2010. Anamnesis showed he was involved in mushroom production beginning in the summer of 2010. His temperature on admission was 36.6°C and he had a normal blood pressure (135/90 mmHg). Bilateral fine crackles were audible in the base of both lungs. Pulmonary function tests showed a mild restrictive pattern with decreased DLco and a PaO(2) of 65 mmHg, Chest CT scan revealed reticulo-nodular shadows, slight ground glass opacities, liner atelectasis, and subpleural opacities in both lung fields. Bronchoscopy was normal but cytological examination of BAL revealed a predominant lymphocytosis (55%). Serum precipitins to the Shiitake mushroom spores were positive (3 precipitins arcs with high intensity) and as a result we advised the patient to cease his mushr...Continue Reading

References

Oct 1, 1992·Internal Medicine·S MatsuiM Mori
Jan 1, 1992·American Journal of Industrial Medicine·W SandersonF Green
Jan 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J SastreS B Lehrer
Jan 1, 1991·Journal of the American Academy of Dermatology·K TarvainenT Rantanen
Dec 9, 1967·British Medical Journal·A Sakula
Jan 10, 2002·Respiratory Medicine·H TanakaS Abe
Jul 5, 2003·American Journal of Respiratory and Critical Care Medicine·Yves LacasseUNKNOWN HP Study Group
Sep 5, 1959·Journal of the American Medical Association·L S BRINGHURSTJ GERSHON-COHEN
Jan 20, 2005·American Journal of Respiratory and Critical Care Medicine·Jordan N FinkYasuyuki Yoshizawa
Jul 5, 2006·Orphanet Journal of Rare Diseases·Yves Lacasse, Yvon Cormier
Jan 24, 2007·AJR. American Journal of Roentgenology·C Isabela S SilvaNestor L Müller
May 9, 2007·The Medical Journal of Australia·Ryan F HoyChristine F McDonald

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Citations

Feb 5, 2013·Clinical and Translational Allergy·Ioana O Agache, Liliana Rogozea
Aug 22, 2014·International Journal of Occupational Medicine and Environmental Health·Valerio PravettoniMarta Piantanida
Jan 26, 2018·Journal of Occupational and Environmental Hygiene·Brett J GreenDonald H Beezhold
Jan 14, 2016·Current Opinion in Pulmonary Medicine·Tara M Nordgren, Kristina L Bailey
Oct 22, 2019·Pediatric Pulmonology·Stéphanie WaninVéronique Houdouin
Feb 14, 2020·Annals of Work Exposures and Health·James R CouchMark M Methner

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