PMID: 45581Jul 1, 1978

Hypersensitivity reaction to sulfasalazine with severe hepatotoxicity

R P SotolongoK G Ishak


Sulfasalazine hepatotoxicity has been poorly documented in the literature. We report a case of a young female with inflammatory bowel disease who developed severe hepatotoxicity as part of a systemic hypersensitivity reaction to sulfasalazine. The clinical, biochemical, and histopathological features resemble those of sulfonamide-induced hepatic injury. Although rare, our case as well as previous reports indicate the serious nature of the illness.

Related Concepts

Sulfasalazin medac
Drug-Induced Acute Liver Injury
Sulfonamide Anti-Infective Agents
Inflammatory Bowel Diseases
Drug Allergy

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