PMID: 8596322Mar 2, 1996Paper

Hypersensitivity reactions associated with 5- hydroxytryptamine(3)-receptor antagonists: a class effect?

Lancet
V Kataja, K M de Bruijn

Abstract

The 5-hydroxytryptamine(3) (5-HT(3))- receptor antagonists, granisetron, ondansetron, and tropisetron are effective anti-emetic medications for use during chemotherapy for cancer and they are generally well tolerated. Their adverse event profiles broadly overlap and include headache and gastrointestinal symptoms, especially constipation. Hypersensitivity reactions have been reported very rarely. We describe two patients who developed severe hypersensitivity reactions following exposure to a 5- HT(3) receptor antagonist after having experienced mild to moderate hypersensitivity symptoms following previous exposure to a different 5-HT(3) receptor antagonist. A literature search on hypersensitivity reactions associated with these drugs suggests that these are the first reported instances of cross-reactive hypersensitivity. There may be a drug class effect, and we caution against switching to another 5-HT(3) receptor antagonist in patients who have suffered even mild hypersensitivity reactions during previous therapy with 5- HT(3) receptor antagonist.

References

Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C EvansR C Coombes
Oct 15, 1993·Annals of Internal Medicine·M ChenH Gallo-Torres

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Citations

Jul 9, 1999·Journal of Clinical Anesthesia·E Figueredo, L G Canosa
Oct 6, 2010·Journal of Pediatric Hematology/oncology·Hacı Ahmet DemirMünevver Büyükpamukçu
Jun 18, 2011·Journal of Paediatrics and Child Health·John Tan, Sam Mehr
Aug 16, 2008·Journal of Medical Case Reports·Karishma K MehraLata S Bichile
May 25, 1996·Lancet·C FrigerioF Spertini
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·John LeungAleena Banerji

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