PMID: 11930904Apr 5, 2002Paper

Hypersensitivity reactions in mouse airways after a single and a repeated hapten challenge

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
A H van HouwelingenF P Nijkamp

Abstract

In this study, we examined the effect of a single and a repeated hapten-challenge on inflammatory processes in the airways of mice undergoing a hapten-induced non-IgE mediated hypersensitivity reaction. BALB/c mice were skin-sensitized with the hapten dinitroflourobenzene (DNFB) and intra-airway challenged with dinitrobenzene sulphonic acid (DNS). Mucosal exudation, tracheal vascular permeability, cellular accumulation, and serum murine mast cell protease (MMCP) were investigated at different time points after the first DNS-challenge and 30 min after a repeated DNS-challenge. MMCP levels in serum were increased at all time points after single challenge and repeated challenge. Increased vascular permeability as determined by Monastral blue staining, was found in the trachea of DNFB-sensitized mice after single DNS-challenge. A second exposure to DNS profoundly enhanced the Monastral blue labeling of the tracheal blood vessels of DNFB-sensitized mice. Furthermore, increased mucosal exudation and polymorphonuclear cell (PMN) accumulation were present in DNFB-sensitized mice compared to vehicle-sensitized animals after the first DNS challenge. Increased mucosal exudation, vascular permeability, and PMN accumulation are prominent in...Continue Reading

References

May 1, 1983·The Journal of Experimental Medicine·H van LoverenP W Askenase
Dec 1, 1994·American Journal of Respiratory and Critical Care Medicine·J GarssenH Van Loveren
Oct 1, 1996·American Journal of Respiratory and Critical Care Medicine·H ScheerensH Van Loveren
Mar 17, 1999·British Journal of Pharmacology·P BalukD M McDonald

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Citations

Oct 16, 2004·American Journal of Respiratory and Critical Care Medicine·Ian A YangStephen T Holgate
Jun 17, 2008·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Akihiko ItoJunko Oonuma
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Josje H E Arts, C Frieke Kuper
Feb 16, 2020·International Journal of Environmental Research and Public Health·Chiara LoriniGuglielmo Bonaccorsi
Jun 15, 2007·Alternatives to Laboratory Animals : ATLA·Ian KimberUNKNOWN European Centre for the Validation of Alternative Methods

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