PMID: 1079195Feb 1, 1975Paper

Hypersensitivity reactions in small intestine. I Thymus dependence of experimental 'partial villous atrophy'

Gut
A Ferguson, E E Jarrett

Abstract

Rats infected with the intestinal nematode Nippostrongylus brasiliensis have crypt hyperplasia with villous atrophy in affected areas of the small intestine. In thymus-deprived (B) rats the course of infection is prolonged but, despite the presence of many worms in the intestinal lumen, villi and crypts appear largely normal. This suggests that the tissue damaged associated with N. brasilliensis infection is caused, not by the worms, but by a local thymus-dependent immune reaction. There is some evidence to implicate lymphocytes rather than antibodies in this reaction. It is already know that T-cell-associated damage to the small intestine, such as occurs in allograft rejection, produces subtotal villous atrophy. The present findings suggest that when T cell react locally with helminth antigens a similar type of damage occurs. The presence of a local cell-mediated immune reaction may be the common factor which causes villous atrophy and crypt hyperplasia in many small intestinal diseases, eg, viral enteritis, giardiasis, cow's milk allergy, and coeliac disease.

References

Aug 2, 1974·Nature·E E Jarrett, A Ferguson
May 1, 1973·Archives of Disease in Childhood·G L Barnes, R R Townley
Jan 15, 1974·International Journal of Cancer. Journal International Du Cancer·E W LamonE Klein
May 1, 1973·Canadian Anaesthetists' Society Journal·D W Davies, D J Steward
Jun 21, 1973·The New England Journal of Medicine·D S SchreiberJ S Trier
Jan 1, 1973·International Archives of Allergy and Applied Immunology·L S Kind, B Macedo-Sobrinho
Jun 1, 1963·Experimental Parasitology·F W JENNINGSG M URQUHART

Citations

May 1, 1980·European Journal of Pediatrics·M J Brueton
Oct 1, 1984·Biulleten' eksperimental'noĭ biologii i meditsiny·G G Aparovich, V A Trufakin
Jan 1, 1992·Digestive Diseases and Sciences·R D'IncaM H Perdue
Jul 26, 2006·Digestive Diseases and Sciences·Ana Luiza Werneck-SilvaAytan Miranda Sipahi
Oct 1, 1979·Cellular Immunology·D F Manson-SmithD M Parrott
Apr 1, 1977·International Journal for Parasitology·A M Scofield
Jun 1, 1982·International Journal for Parasitology·K J Cheema, A M Scofield
Dec 1, 1992·International Journal for Parasitology·N C Smith
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·R Moqbel
Apr 1, 1981·Veterinary Immunology and Immunopathology·P J BrownD M Parrott
Sep 1, 1982·Veterinary Immunology and Immunopathology·M E Rose, P Hesketh
May 1, 1984·Veterinary Immunology and Immunopathology·T J Newby, C R Stokes
Sep 1, 1982·Molecular and Biochemical Parasitology·G A Castro, Y Harari
Jan 1, 1989·Parasitology Today·G A Castro
Dec 1, 1990·Parasitology Today·A BuretM E Olson
Jan 1, 1978·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A M Scofield
Jul 1, 1987·Baillière's Clinical Gastroenterology·D Robertson, R Wright
Jan 1, 1987·Parasitology·P H Holmes
Mar 1, 1992·Parasite Immunology·P GarsideA M Mowat
Aug 1, 1978·Australian and New Zealand Journal of Medicine·V M DuncombeR L Crouch

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.