PMID: 9439154Jun 1, 1997Paper

Hypersensitivity to acid in ulcer-like functional dyspepsia

The Korean Journal of Internal Medicine
H J SonJ C Rhee

Abstract

The mechanism of pain sensation in patients with ulcer-like functional dyspepsia is unclear and there are no guidelines for its treatment. Whilst much research and many pharmacological treatments have provided symptomatic relief of ulcer-like functional dyspepsia through control of acid secretion, the role of acid in ulcer-like functional dyspepsia is unknown. We carried out this study to investigate the role of hypersensitivity to acid in the sensation of pain in ulcer-like functional dyspepsia by direct administration of acid into stomach. Twelve patients with ulcer-like functional dyspepsia (5 male, 7 female, mean age 41.0 years old, 7 with mild chronic superficial gastritis, 2 with metaplastic gastritis and 3 with normal endoscopic findings) and seven healthy control subjects (3 male, 4 female, mean age 36.0 years old, 7 with normal endoscopic findings) participated in the study. After overnight fasting, a nasogastric sump tube was inserted and its tip was positioned in the antrum under fluoroscopic guidance. Normal saline or 0.1N hydrochloric acid was administered in random and single blind cross over fashion. The test was considered positive only if similar pain developed-similar to that experienced by the patient under n...Continue Reading

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Citations

Apr 21, 2018·Frontiers in Systems Neuroscience·Amanda J Page, Hui Li
Nov 1, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marion DanzerPeter Holzer
Dec 7, 2011·Journal of Gastroenterology and Hepatology·Hiroto MiwaYoung-Tae Bak
Jan 10, 2020·Journal of Neurogastroenterology and Motility·Jung Hwan OhUNKNOWN Functional Dyspepsia Research Group and Clinical Practice Guidelines Group Under the Korean Society of Neurogastroenterology
Feb 18, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P HolzerA Heinemann
Apr 24, 2012·Journal of Neurogastroenterology and Motility·Hiroto MiwaYoung-Tae Bak
Jun 27, 2007·Alimentary Pharmacology & Therapeutics·H MiwaK Haruma
Apr 8, 2003·Drugs·Vincenzo StanghelliniRoberto Corinaldesi

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