PMID: 16518074Mar 7, 2006Paper

Hypersensitivity to hydroxyl radicals in rat basilar artery after subarachnoid hemorrhage

Journal of Pharmacological Sciences
Tsuyoshi NishihashiKazuyoshi Kurahashi

Abstract

Vasospasm after subarachnoid hemorrhage (SAH) is a serious complication and we have been investigating the relationship between vasoconstrictors and vasospasm after SAH. The present study was designed to investigate the vasocontractile responses to reactive oxygen species in isolated rat basilar arteries from the control and experimental SAH rats. Contractile responses to hydroxyl radicals in basilar arteries from SAH rats were 3-6-fold higher than those in control rats. The present results clearly indicate that hypersensitivity to hydroxyl radicals may contribute to the vasospasm after SAH.

References

Jul 1, 1989·The American Journal of Physiology·Z S Katusic, P M Vanhoutte
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Mar 10, 2001·Stroke; a Journal of Cerebral Circulation·T MoriT Asano
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Sep 15, 2004·European Journal of Pharmacology·Jianfeng LiBurton M Altura
May 10, 2005·European Journal of Pharmacology·Tsuyoshi NishihashiKazuyoshi Kurahashi

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Citations

Apr 13, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hilal AyogluBektas Acikgoz
Apr 7, 2009·Journal of Pharmacological Sciences·Terumasa HashimotoKazuo Honda
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iwona Jarocka-KarpowiczZenon Dionizy Mariak
Nov 6, 2020·Neurocritical Care·Rebecca A ReynoldsReid C Thompson

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