PMID: 16639064Apr 28, 2006Paper

Hypertaurinemia in bile duct-ligated rats after surgery: the effect of gut endotoxin restriction on organ fluxes and oxidative status

JPEN. Journal of Parenteral and Enteral Nutrition
A P HoudijkP A van Leeuwen

Abstract

Surgery in obstructive jaundice is associated with complications related to gut-derived endotoxemia. The organs involved in these complications, including liver, kidneys, and gut, are important in the metabolism of taurine, which is implicated in bile acid conjugation and has antioxidative effects. Taurine organ metabolism and liver oxidative status were studied in bile duct-ligated rats (BDL) after laparotomy. Oral cholestyramine treatment inhibits gut-derived endotoxemia and was used to evaluate the role of endotoxin. In BDL rats, postoperative plasma taurine levels were higher compared with SHAM (p < .0001). Cholestyramine treatment reduced plasma taurine in BDL rats (p < .005), but levels remained higher compared with SHAM groups (p < .0001). In contrast to a liver uptake of taurine in SHAM rats, a release from livers of BDL rats was found (p < .005). Cholestyramine treatment in BDL rats resulted in a liver uptake of taurine (p < .05 vs BDL). A higher uptake of taurine by the kidneys was found in both BDL animals after surgery and SHAM controls (p < .005); however, cholestyramine had no effect. A release of taurine from the gut was found in the SHAM groups, which was reversed in both BDL groups (p < .01). Cholestyramine low...Continue Reading

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Citations

Jun 16, 2011·Neurochemical Research·Filiz Sezen BircanGonca Ozan
Feb 7, 2012·Metabolism: Clinical and Experimental·Mireille F M van StijnPaul A M van Leeuwen
Nov 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiayue LiuGuixin Zhang

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