Hypertension: a disorder of volume control? What is the evidence?

Advances in Chronic Kidney Disease
Aubrey R Morrison, Graeme Mindel

Abstract

Hypertension is a common trait worldwide and is responsible for a major expenditure of health-care dollars in the United States. Although the etiological factors responsible for the expression of this phenotype are complex, several experimental and clinical observations point to a major role of the kidney as responsible. Genetic studies of uncommon diseases, which express monogenetic inheritance, all have in common a dysregulation of sodium balance and volume expansion. Furthermore, epidemiological data suggest an increased incidence of hypertension in communities with high excretory rates of sodium. Experimental data also suggest that low birth weight is associated with an increase in the frequency of hypertension later in life and raises the possibility that intrauterine imprinting may contribute to the expression of the phenotype. Indeed, data suggesting up-regulation of the Na(+)/K(+)/2Cl(-) and thiazide-sensitive transporters in low-birth-weight animals may provide the physiological basis for these observations. Finally, subtle gain of function mutations in one or more of these transporters may unmask defects in volume homeostasis with increasing salt intake.

References

Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Oct 27, 1983·The New England Journal of Medicine·J J CurtisA G Diethelm
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·H S KimO Smithies
Dec 1, 1993·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·X JeunemaitreP Corvol
Jun 8, 1996·BMJ : British Medical Journal·C M LawC Osmond
Nov 5, 1997·The Journal of Biological Chemistry·R A ShimketsC M Canessa
Mar 10, 2001·Cell·R P LiftonD S Geller
Jun 19, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Manning, V M Vehaskari
Aug 11, 2001·Science·F H WilsonR P Lifton
Jun 13, 2002·American Journal of Physiology. Renal Physiology·Jennifer ManningV Matti Vehaskari
Mar 26, 2003·The Journal of Biological Chemistry·Pauline C HenryDaniela Rotin
Sep 1, 1955·Annals of Internal Medicine·G W PICKERING

❮ Previous
Next ❯

Citations

Feb 25, 2006·The Tohoku Journal of Experimental Medicine·Soisungwan SatarugMichael R Moore
Sep 1, 2010·Indian Journal of Microbiology·M VenkateshwarGopal Reddy
Oct 27, 2005·Chemistry : a European Journal·Bogdan MarciniecIreneusz Kownacki
Aug 14, 2009·Cognitive Behaviour Therapy·Julia MullerChristine Knaevelsrud
Jul 11, 2006·Journal of Proteome Research·Yulan WangJeremy K Nicholson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.