PMID: 11926202Apr 3, 2002Paper

Hypertension after renal transplantation and polymorphism of genes involved in essential hypertension: ACE, AGT, AT1 R and ecNOS

Clinical Nephrology
El-Essawy A BassetF Berthou

Abstract

Arterial hypertension (HT), secondary to cyclosporine A (CsA) used as main immunosuppressive treatment in renal transplantation (RTx), is very frequent (70%), usually severe and explained mostly by vasoconstriction of the glomerular afferent arteriole with secondary sodium and water retention. In a retrospective study, we have analyzed 294 consecutive recipients receiving a first renal cadaveric allograft and all treated with CsA (the majority with triple therapy). We studied, by molecular biology, the polymorphism of genes previously implicated in essential HT such as: angiotensin-converting enzyme (ACE: II, ID and DD), angiotensinogen (AGT: MM, MT and TT), angiotensin II type 1 receptor (AT1-R: AA, AC and CC) and endothelial constitutive nitric oxide synthase (ecNOS: aa, ab and bb), and correlated the data to the prevalence and severity of post-Tx HT. This cohort included 195 (66%) males and 99 females with a mean age of 42 years at time of Tx. The presence and severity of post-Tx HT were indicated by initial persistent blood pressure over 140/90 mmHg with the need for at least one anti-hypertensive drug and by the number of anti-HT medications required to achieve its control. The distribution of the specific alleles and geno...Continue Reading

Citations

Sep 15, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R BüscherPeter F Hoyer
Oct 18, 2006·BMC Nephrology·Gaurav TripathiSuraksha Agrawal
Aug 24, 2011·Journal of Inflammation·Manal F ElshamaaDalia A Abd-El Haleem
Apr 30, 2003·Pharmacogenomics·Yoram Yagil, Chana Yagil
Aug 20, 2011·Clinical and Experimental Hypertension : CHE·Mariano FerraressoAlberto Edefonti
Feb 5, 2008·Clinical Biochemistry·Gaurav TripathiSuraksha Agrawal
Jul 15, 2004·Seminars in Nephrology·Ingrid H C VosTon J Rabelink
Aug 27, 2013·Journal of Receptor and Signal Transduction Research·Tian-Biao ZhouZong-Pei Jiang
Sep 26, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Indraneel BhattacharyyaDonald M Cohen
Jan 6, 2010·Clinical Transplantation·Grażyna DutkiewiczKazimierz Ciechanowski
Nov 29, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Hanan M El-Gowelli, Mahmoud M El-Mas
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