Hypertension and abnormalities of carbohydrate metabolism possible role of the sympathetic nervous system

American Journal of Hypertension
L A SechiE Bartoli

Abstract

To investigate the relationships between the sympathetic nervous system (SNS) and parameters of glucose metabolism in arterial hypertension, daily urinary excretion of catecholamines and plasma glucose, insulin, and C-peptide response to an oral glucose load (OGL) have been evaluated in 77 untreated patients with mild-to-moderate essential hypertension and in 31 normotensive controls. Urinary excretion of norepinephrine (UNE) was positively correlated with body mass index and with plasma glucose levels both at fast and after OGL. No correlations were found between urinary excretion of catecholamines and plasma insulin and C-peptide levels both at fast and in response to OGL. Because the frequency distribution of UNE was bimodal, hypertensive subjects were separated into two subgroups using an arbitrary cutoff, and the parameters of glucose metabolism were compared. Subjects with UNE > 205 microg/day had greater levels of fasting glucose and greater glycemic response to OGL than subjects with UNE < 205 microg/day, whereas no significant differences between the groups were found in fasting and stimulated plasma insulin and C-peptide. Thus, activation of SNS is related to glucose tolerance but not hyperinsulinemia and insulin hype...Continue Reading

Citations

Jul 23, 1999·Annals of the New York Academy of Sciences·H Rupp
Jun 20, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Paul Ernsberger, Richard J Koletsky
Aug 16, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Michiko AbeJun Nakura
Mar 5, 2016·The Journal of Clinical Hypertension·Josiane M MottaHeno F Lopes
Mar 28, 2002·Diabetes·Leonardo A SechiSergio De Marchi
Jan 27, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S RohrmannE A Platz
Aug 1, 2006·Journal of Hypertension·Giorgio SoardoLeonardo A Sechi
Sep 8, 2006·The Journal of Clinical Hypertension·Francisco J Mena-MartínUNKNOWN Hortega Study Investigators

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