PMID: 10559023Nov 13, 1999

Hypertension and endothelial dysfunction in apolipoprotein E knockout mice

Arteriosclerosis, Thrombosis, and Vascular Biology
R YangH Jin

Abstract

Mice lacking ApoE (Apoe(-/-)) develop initially hypercholesterolemia and lastly atherosclerosis. This study examined hemodynamics and endothelial function in 6-week-old Apoe(-/-) mice with hypercholesterolemia only, 7.5-months-old Apoe(-/-) mice with both hypercholesterolemia and atherosclerosis, and age matched controls. One day after implantation of catheters into the carotid artery, arterial pressure was measured in conscious, unrestrained mice. Compared with the respective controls, there was a significant increase in arterial pressure and the ratio of left ventricular weight to body weight in 7.5-month-old Apoe(-/-) mice but not in 6-week-old Apoe(-/-) mice. Histopathological analysis demonstrated significant renal artery disease in the form of extensive atheromatous plaques only in 7.5-month-old Apoe(-/-) mice, whereas no atherosclerotic lesions were found in 6-week-old Apoe(-/-) mice. For evaluation of endothelial function, a laser Doppler perfusion imager with a computer-controlled optical scanner was used to measure cutaneous blood perfusion on the dorsal side of one hind paw before and after topical application of mustard oil, which is known to induce nitric oxide-mediated vasodilation. The mustard oil treatment elici...Continue Reading

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Related Concepts

Arterial Pulse Pressure
Epicholesterol
Plaque, Atherosclerotic
Mustard oil
Immediate Hypersensitivity
Common Carotid Artery
Entire Carotid Artery
Mustard (Food)
Cilostazol
Fuchs Endothelial Dystrophy

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