PMID: 10559023Nov 13, 1999

Hypertension and endothelial dysfunction in apolipoprotein E knockout mice

Arteriosclerosis, Thrombosis, and Vascular Biology
R YangH Jin


Mice lacking ApoE (Apoe(-/-)) develop initially hypercholesterolemia and lastly atherosclerosis. This study examined hemodynamics and endothelial function in 6-week-old Apoe(-/-) mice with hypercholesterolemia only, 7.5-months-old Apoe(-/-) mice with both hypercholesterolemia and atherosclerosis, and age matched controls. One day after implantation of catheters into the carotid artery, arterial pressure was measured in conscious, unrestrained mice. Compared with the respective controls, there was a significant increase in arterial pressure and the ratio of left ventricular weight to body weight in 7.5-month-old Apoe(-/-) mice but not in 6-week-old Apoe(-/-) mice. Histopathological analysis demonstrated significant renal artery disease in the form of extensive atheromatous plaques only in 7.5-month-old Apoe(-/-) mice, whereas no atherosclerotic lesions were found in 6-week-old Apoe(-/-) mice. For evaluation of endothelial function, a laser Doppler perfusion imager with a computer-controlled optical scanner was used to measure cutaneous blood perfusion on the dorsal side of one hind paw before and after topical application of mustard oil, which is known to induce nitric oxide-mediated vasodilation. The mustard oil treatment elici...Continue Reading


Dec 28, 2011·Endocrine·Vildan Bozok CetintasZuhal Eroglu
Mar 4, 2014·Vascular Pharmacology·XiaoOu MaoDavid A Greenberg
Jun 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·J L ClelandA Cuthbertson
Oct 10, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Wenquan NiuDingliang Zhu
Nov 25, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Wenquan NiuYue Qi
Dec 15, 2000·Kidney International·O SmithiesM H Edgell
Jun 27, 2003·Journal of Cardiovascular Pharmacology·Sandrine PonsChristine Richer
Apr 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter J KuhlencordtGeorg Ertl
Feb 15, 2012·Journal of Biomedical Science·Elisardo C VasquezSilvana S Meyrelles
Nov 16, 2011·Lipids in Health and Disease·Silvana S MeyrellesElisardo C Vasquez
Apr 2, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Hisao OnozukaAkira Kitabatake
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Aron M TroenJacob Selhub
Oct 10, 2007·Archives of Medical Research·Breno V NogueiraElisardo C Vasquez
Jun 8, 2012·Journal of Pharmacological Sciences·Narumi Hashikawa-HobaraHiromu Kawasaki
Mar 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Takuya MatsumotoZvonimir S Katusic
Jul 23, 2003·British Journal of Pharmacology·Fan JiangGregory J Dusting
Nov 3, 2009·Journal of Pharmacological Sciences·Wenhao CuiChihiro Yabe-Nishimura
Jul 18, 2003·Current Eye Research·John M OngCristina M Kenney
May 3, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eric E LloydRobert M Bryan
Jan 11, 2017·Mediators of Inflammation·Barbara ToffoliStella Bernardi
Apr 12, 2003·Clinical and Experimental Pharmacology & Physiology·Sharyn M FitzgeraldGöran Bergström
Jan 9, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Irene J AnderssonSandra T Davidge
Sep 19, 2018·Nature Genetics·Evangelos EvangelouMillion Veteran Program
Jul 8, 2020·International Journal of Molecular Sciences·Amanda St PaulMichael V Autieri
Aug 15, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Min WenCharles E Alpers


May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J A PiedrahitaN Maeda
Jan 1, 1987·Acta Medica Scandinavica. Supplementum·G K Hansson, G Bondjers
Aug 1, 1983·Pharmacology, Biochemistry, and Behavior·W DyrA Bidzinski
Nov 1, 1981·The Journal of Urology·A C Novick
Jan 1, 1995·The American Journal of Cardiology·J A Hill
Jan 1, 1994·Basic Research in Cardiology·D G Harrison
Jan 1, 1994·Thrombosis Research·G Noll, T F Lüscher
Apr 1, 1993·IEEE Transactions on Bio-medical Engineering·K WårdellG E Nilsson
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J L Breslow
May 1, 1993·Medical & Biological Engineering & Computing·A Jakobsson, G E Nilsson
Dec 1, 1996·Molecular Medicine Today·H Bult
Jul 1, 1997·American Journal of Hypertension·A SimonJ Levenson
Jun 17, 1998·The Journal of Clinical Investigation·T MuroharaJ M Isner
Jun 27, 1998·Biochemical and Biophysical Research Communications·V N Trieu, F M Uckun

Related Concepts

Arterial Pulse Pressure
Plaque, Atherosclerotic
Mustard oil
Immediate Hypersensitivity
Common Carotid Artery
Entire Carotid Artery
Mustard (Food)
Fuchs Endothelial Dystrophy

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