Hypertension and Ischemic Stroke After Aflibercept for Retinopathy of Prematurity

International Medical Case Reports Journal
Fatemeh BazvandHamid Riazi-Esfahani

Abstract

Retinopathy of prematurity is the leading cause of preterm infants' blindness. The preferred method for the management of aggressive posterior ROP is the anti-vascular endothelial growth factor (anti-VEGF). However, systemic and ocular adverse effects of anti-VEGF drugs remain a concern. A case report of a preterm infant with a history of hypertension underwent intravitreal injection of aflibercept at the 50-week postmenstrual age because of aggressive posterior retinopathy of prematurity (ROP) in both eyes. Seven days after the intravitreal administration of aflibercept, he has a hypertension crisis and an ischemic stroke. Serial fundoscopies implied complete arrest of vascularization till seven months after receiving treatment. We report a case of an infant, with a history of hypertension, had an ischemic stroke just one week after the intravitreal injection of aflibercept for aggressive posterior ROP. We can conclude that in cases of preterm infants with systemic comorbidities, like uncontrolled hypertension, that predispose patients to thromboembolic events, we should be cautious about the potential increase in the risk of thromboembolic events after administration of anti-vascular endothelial growth factor agents (anti-VEG...Continue Reading

References

Feb 18, 2011·The New England Journal of Medicine·Helen A Mintz-HittnerUNKNOWN BEAT-ROP Cooperative Group
Nov 26, 2013·Ophthalmology·Paul E BeaumontHyong K Kang
Mar 24, 2015·Journal of Pediatric Ophthalmology and Strabismus·Michael A Klufas, R V Paul Chan
Jun 1, 2016·Pediatrics·Julie MorinUNKNOWN Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network Investigators

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Citations

Jul 6, 2021·Journal of Ophthalmology·B SobolewskaF Ziemssen

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Methods Mentioned

BETA
PMA

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