Abstract
Substantial evidence indicates that hypertension is a major contributor to the development of end-stage renal disease in most patients. However, such risk ranges from being fairly low in essential hypertension to a marked increase in susceptibility to hypertensive injury in patients with chronic kidney disease, including diabetic nephropathy. Studies in experimental animal models using blood pressure radiotelemetry have provided significant insights into the quantitative relationships between blood pressure and renal damage and the importance of protective renal autoregulatory capacity as a determinant of such differences in susceptibility to hypertensive injury. Moreover, such investigations have also emphasized the predominant importance of achieving normotension per se over the selection of particular antihypertensive regimens, including renin-angiotensin system blockade, in slowing the progression of chronic kidney disease.
References
Oct 1, 1994·Kidney International·K A GriffinA K Bidani
Jul 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J R Neuringer, B M Brenner
Oct 3, 1999·Kidney International·P K ChristensenH H Parving
Sep 29, 2000·Circulation Research·K Loutzenhiser, R Loutzenhiser
Dec 26, 2001·Hypertension·P SvenssonJ Ostergren
Nov 21, 2002·JAMA : the Journal of the American Medical Association·Jackson T WrightUNKNOWN African American Study of Kidney Disease and Hypertension Study Group
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Dec 28, 2002·Diabetes Care·Per K ChristensenHans-Henrik Parving
Mar 13, 2003·Kidney International·Karen A GriffinAnil K Bidani
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Nov 15, 2003·Lancet·Fiona Turnbull, UNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Apr 29, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN Kidney Disease Outcomes Quality Initiative (K/DOQI)
Sep 29, 2004·Hypertension·Anil K Bidani, Karen A Griffin
Dec 22, 2004·Hypertension·Theodore W KurtzUNKNOWN Subcommittee of Professional and Public Education of the American Heart Association
Apr 27, 2005·Archives of Internal Medicine·Mahboob RahmanThomas Wiegmann
Dec 13, 2005·Lancet·Juan P CasasRaymond J MacAllister
Jan 13, 2006·The New England Journal of Medicine·Fan Fan HouRen Wen Geng
May 10, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rodger Loutzenhiser
Citations
Feb 2, 2008·American Journal of Nephrology·Wenyuan ZhaoYao Sun
May 22, 2013·The Canadian Journal of Cardiology·S Lucy Roche, Candice K Silversides
Jan 19, 2012·Renal Failure·Nan ChenJin-Yuan Zhang
May 7, 2015·BioMed Research International·Catherina A CuevasCarlos P Vio
Mar 8, 2007·The Annals of Pharmacotherapy·Benjamin W Van Tassell, Mark A Munger
Jan 22, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yagiz UresinAndrew Satlin
Mar 27, 2007·Clinical and Experimental Nephrology·Masayuki Tanemoto