PMID: 16523000Mar 9, 2006Paper

Hypertension and kidney damage

The Journal of Clinical Hypertension
Karen A Griffin

Abstract

Substantial evidence indicates that hypertension is a major contributor to the development of end-stage renal disease in most patients. However, such risk ranges from being fairly low in essential hypertension to a marked increase in susceptibility to hypertensive injury in patients with chronic kidney disease, including diabetic nephropathy. Studies in experimental animal models using blood pressure radiotelemetry have provided significant insights into the quantitative relationships between blood pressure and renal damage and the importance of protective renal autoregulatory capacity as a determinant of such differences in susceptibility to hypertensive injury. Moreover, such investigations have also emphasized the predominant importance of achieving normotension per se over the selection of particular antihypertensive regimens, including renin-angiotensin system blockade, in slowing the progression of chronic kidney disease.

References

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Citations

Feb 2, 2008·American Journal of Nephrology·Wenyuan ZhaoYao Sun
May 22, 2013·The Canadian Journal of Cardiology·S Lucy Roche, Candice K Silversides
May 7, 2015·BioMed Research International·Catherina A CuevasCarlos P Vio
Mar 8, 2007·The Annals of Pharmacotherapy·Benjamin W Van Tassell, Mark A Munger
Jan 22, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yagiz UresinAndrew Satlin
Mar 27, 2007·Clinical and Experimental Nephrology·Masayuki Tanemoto

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