PMID: 8590792Oct 1, 1995Paper

Hypertension and non-insulin-dependent diabetes. A comparison between an angiotensin-converting enzyme inhibitor and a calcium antagonist

Acta Diabetologica
G CrepaldiG Giustina

Abstract

The effects of the angiotensin-converting enzyme lisinopril were compared with those of the calcium antagonist nifedipine in 162 non-insulin-dependent diabetic hypertensive patients for a 24-week period. In 83 and 79 patients, respectively, lisinopril and slow-release nifedipine produced similar reductions in blood pressure (systolic/diastolic: -16/-13 mmHg supine and -14/-11 mmHg standing after lisinopril; -15/-12 mmHg supine and -14/-11 mmHg standing nifedipine). Fasting and post-prandial plasma glucose, glycosylated haemoglobin and plasma lipids appeared to be unaffected by either agent. Also, 28% of the patients on lisinopril and 30% of those on nifedipine presented microalbuminuria. Both drugs induced a reduction in the albumin excretion rate (AER). The geometric mean x:tolerance factor of the reduction in AER among the 23 microalbuminuric patients on lisinopril (-10.0 x:1.3 micrograms/min) was greater, though not significantly so, than that observed in the 26 on nifedipine (-0.9 x 1.2 micrograms/min). Moreover, lisinopril appeared to be better tolerated than nifedipine in our study population. Microalbuminuria is an important risk factor for cardiovascular mortality in non-insulin-dependent diabetic patients as well as in...Continue Reading

References

Nov 2, 1963·Lancet·H KEEN, C CHLOUVERAKIS

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Citations

Oct 19, 2011·Journal of General Internal Medicine·Emaad M Abdel-RahmanAlaa S Awad
Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·W WienenC Audeval-Gerard
Jul 15, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nicolás R RoblesGuido Grassi
May 26, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·S M Marshall
Nov 10, 2006·Diabetes/metabolism Research and Reviews·György Jermendy, Piero Ruggenenti
Sep 2, 2005·Journal of the American Society of Nephrology : JASN·Giovanni F M StrippoliJonathan C Craig
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Jicheng LvGiovanni F M Strippoli
Aug 3, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B NielsenA Flyvbjerg

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