Hypertension and renal impairment in patients with cystinuria: findings from a specialist cystinuria centre

Urolithiasis
Francesca KumKay Thomas

Abstract

Higher blood pressures (mean systolic difference 16.8 mmHg) when compared to matched individuals are already reported in patients with calcium urolithiasis. We present the prevalence of hypertension and renal impairment in patients with cystinuria from our specialist single centre. We analysed our prospective database of adult patients with cystinuria who attend our cystinuria service. This included details of the medical and operative management of their disease. Descriptive statistics were used to analyse and present the data. 120 patients were included with a median age of 40 (19-76) years, 66 were male (55%) and 54 were female (45%). 54/120 patients (45%) were taking medications to prevent stone formation. 78% (94/120) patients reported having undergone one or more stone-related procedure. 59% (55/94) of these having required at least one PCNL or open procedure during their lifetime. Prevalence of hypertension was 50.8% (61/120), and double in males compared to females (62.1% vs. 37.0%, P = 0.0063). Mean baseline creatinine was 88.2 (49-153) µmol/l and eGFR was 77.6 (32-127) ml/min/1.73 m2. When categorized by CKD stage, only 24.6% (27% vs. 21%, M vs. F) patients had normal renal function (being an eGFR > 89 ml/min/1.73 m2)...Continue Reading

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Citations

Nov 8, 2020·Nature Reviews. Urology·Ashley AlfordJody Lulich
Dec 12, 2020·Journal of Clinical Medicine·Sofna BanjarnahorRenke Maas
Sep 13, 2020·Kidney International·Aude ServaisUNKNOWN Metabolic Nephropathy Workgroup of the European Reference Network for Rare Kidney Diseases (ERKNet) and eUROGEN
Apr 30, 2021·Néphrologie & thérapeutique·Caroline Prot-BertoyeMarie Courbebaisse
Nov 24, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Viola D'AmbrosioPietro Manuel Ferraro

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