Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney.

European Heart Journal
Xiao JiangMaciej Tomaszewski

Abstract

Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute respiratory syndrome coronavirus (SARS-CoV-2)-the cause of coronavirus disease 2019 (COVID-19). However, the effect of renin-angiotensin system (RAS)-inhibition on ACE2 expression in human tissues of key relevance to blood pressure regulation and COVID-19 infection has not previously been reported. We examined how hypertension, its major metabolic co-phenotypes, and antihypertensive medications relate to ACE2 renal expression using information from up to 436 patients whose kidney transcriptomes were characterized by RNA-sequencing. We further validated some of the key observations in other human tissues and/or a controlled experimental model. Our data reveal increasing expression of ACE2 with age in both human lungs and the kidney. We show no association between renal expression of ACE2 and either hypertension or common types of RAS inhibiting drugs. We demonstrate that renal abundance of ACE2 is positively associated with a biochemical index of kidney function and show a strong enrichment for genes responsible for kidney health and disease in ACE2 co-expression analysis. Our results indicate that neither hypertension nor antihypertensive treatm...Continue Reading

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Citations

Jan 11, 2021·The Lancet. Respiratory Medicine·Bryan Williams
Mar 9, 2021·Frontiers in Physiology·Jing-Yi QianBi-Cheng Liu
Apr 2, 2021·Circulation Research·Carmine SavoiaReinhold Kreutz
May 8, 2021·Nature Genetics·James M EalesMaciej Tomaszewski
May 21, 2021·Frontiers in Physiology·Shah-Abas MuhamadAmilia Aminuddin
Jun 18, 2021·Journal of the American Society of Nephrology : JASN·Pamela Matías-GarcíaMelanie Waldenberger
Aug 19, 2021·American Journal of Hypertension·Shigeru Shibata, Takuya Kishi
Nov 19, 2021·European Heart Journal·UNKNOWN Task Force for the management of COVID-19 of the European Society of Cardiology
Nov 19, 2021·European Heart Journal·UNKNOWN Task Force for the management of COVID-19 of the European Society of Cardiology
Jul 30, 2021·Journal of Cardiovascular Pharmacology·Mei PengZhicheng Gong

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Methods Mentioned

BETA
biopsy
PCR
electron microscopy

Software Mentioned

REACTOME
sva
R
TRANSLATE
Nephroseq
Limma
gee R

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