Hypertension associated with venous thromboembolism in patients with newly diagnosed lung cancer

Scientific Reports
Yuhui ZhangChina Venous Thromboembolism VTE Study Group

Abstract

The aim of this study was to evaluate associations between cardiovascular disease (CVD) risk factors and the occurrence of venous thromboembolism (VTE) in patients with lung cancer that might help estimate an individual's risk for VTE. A total of 632 unselected patients with newly diagnosed lung cancer were investigated for VTE within the three months prior to recruitment, and their major CVD risk factors were assessed at the baseline examination. Eighty-six of the 632 (13.6%) developed a VTE event. Multivariate logistic regression analysis, including age, sex, smoking, body mass index, diabetes, dyslipidemia, hypertension and white blood cell count, found that hypertension (OR 1.8; 95% CI 1.0-3.3) and leukocytosis (OR 2.7; 95% CI 1.5-4.8) were significantly associated with VTE in different tumor histology models and that hypertension (OR 1.9; 95% CI 1.1-3.4) and leukocytosis (OR 2.7; 95% CI 1.5-4.7) were also significantly associated with VTE in different tumor stage models. Leukocytosis was linearly associated with hypertension and VTE (P for trend = 0.006), and the ORs for VTE increased with leukocytosis (all P for trend <0.05). In conclusion, hypertension increased the risk of VTE in patients with newly diagnosed lung cance...Continue Reading

References

Feb 26, 1997·JAMA : the Journal of the American Medical Association·S Z GoldhaberC H Hennekens
Apr 11, 2003·The New England Journal of Medicine·Paolo PrandoniAntonio Girolami
Oct 29, 2003·Archives of Internal Medicine·Kaeng W Lee, Gregory Y H Lip
Jun 1, 2005·The Lancet Oncology·Paolo PrandoniAndrea Piccioli
Mar 10, 2006·Thrombosis and Haemostasis·Mats OgrenNils H Sternby
Jul 14, 2006·Journal of Thrombosis and Haemostasis : JTH·L M ReichM Cushman
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·P B van der HagenM Cushman
Aug 30, 2007·American Journal of Hematology·Elisabeth R PompCarine J M Doggen
Dec 19, 2007·Circulation·Walter AgenoPieter W Kamphuisen
Jan 23, 2008·Journal of Thrombosis and Haemostasis : JTH·H K ChewR H White
May 7, 2009·JAMA : the Journal of the American Medical Association·Bakhtawar K MahmoodiUNKNOWN Prevention of Renal and Vascular End-stage Disease (PREVEND) Study Group
Jun 23, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·John A HeitL Joseph Melton
Jul 2, 2009·Journal of Thrombosis and Haemostasis : JTH·M T SeverinsenK Overvad
Nov 17, 2009·American Journal of Public Health·Pamela L LutseyAaron R Folsom
Aug 9, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Luis Corrales-Rodriguez, Normand Blais
Sep 17, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christine M FriedenreichLinda S Cook
Oct 3, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G C ConnollyA A Khorana
Dec 10, 2013·Hematology·Gregory C Connolly, Charles W Francis
Dec 18, 2013·Circulation·Gregory Piazza
Apr 9, 2014·BMC Neurology·Martin SöderholmGunnar Engström

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