Hypertension following denervation of aortic baroreceptors in unanesthetized dogs

Circulation Research
C S Ito, A M Scher

Abstract

After cervical aortic nerve section, mean arterial pressure in the unanesthetized dog increased by an average of 7.4 mm Hg. Following a more extensive denervation of aortic arch receptors by section of intrathoracic vagal branches, arterial pressure increased by 16.7 mm Hg. The above changes were seen in the stable state after the effects of surgery had disappeared. In both cases carotid baroreceptors were functional. After administration of nitroglycerin and phenylephrine subsequent to either denervation procedure, blood pressure changes were larger and heart rate responses were smaller than in the control state. The unanesthetized dog regulates mean arterial pressure at a higher-than-normal pressure after aortic baroreceptor denervation. Reflexes from the aortic baroreceptors continuously participate in the normal control of mean arterial pressure. Section of the cervical aortic nerves only partially denervates aortic baroreceptors. Our findings may be relevant to human essential hypertension.

References

Dec 1, 1976·Clinical Science and Molecular Medicine. Supplement·G ManciaA Zanchetti
Dec 1, 1976·Clinical Science and Molecular Medicine. Supplement·J E Angell-James, M J George
Jan 1, 1974·Clinical and Experimental Pharmacology & Physiology·P I KornerJ B Uther
Jun 1, 1971·The Journal of Physiology·D E Donald, A J Edis
Dec 1, 1969·The American Journal of Physiology·J L AllisonM Kumada
Feb 1, 1970·The American Journal of Physiology·E M Krieger
Oct 1, 1970·Journal of Applied Physiology·E A PhillipsonJ A Nadel
Aug 1, 1967·The American Journal of Physiology·H Irisawa, I Ninomiya
Mar 1, 1956·Circulation Research·J W MCCUBBINI H PAGE
Oct 1, 1964·The American Journal of Physiology·G GLICKE BRAUNWALD

Citations

Aug 1, 1986·Clinical and Experimental Pharmacology & Physiology·V EijzenbachC Borst
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·J F Liard
Jan 1, 1983·Biomaterials, Medical Devices, and Artificial Organs·J E ChimoskeyS W Ely
Aug 1, 2009·Respiratory Physiology & Neurobiology·Thomas E DickKendall F Morris
Aug 1, 1983·The American Journal of Medicine·M A PfeiferJ B Halter
Oct 22, 1979·The American Journal of Cardiology·A Zanchetti
Jul 1, 1985·Clinical and Experimental Pharmacology & Physiology·J H SneekC Borst

Related Concepts

Metazoa
Descending Aorta
Diastolic Blood Pressure
Canis familiaris
Trinitrolong
Pulse Rate
Hypertensive Disease
Mezaton
Pressoreceptors
Pulse Taking

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.