Hypertension in rat offspring subjected to perinatal protein malnutrition is not related to the baroreflex dysfunction

Clinical and Experimental Pharmacology & Physiology
Kássya M Paulino-Silva, João Henrique Costa-Silva

Abstract

This study reports on the effects of maternal protein malnutrition on baroreflex (BR) control of the heart rate and sympathetic nerve activity in the hypertensive male offspring of Wistar rat dams. Wistar rat dams were fed a normal protein (NP) control (17% protein) or a low protein (LP; 8% protein) diet during pregnancy and lactation, and their male offspring were studied when 90 days old. In these animals we evaluated spontaneous and induced BR control, the variability of the cardiovascular system and analyzed a direct recording of lumbar sympathetic nervous activity. The 90 day-old LP conscious rats had increased arterial pressure compared to NP, with enhanced low frequency oscillations of the systolic pressure, but no changes in the spontaneous and induced BR control of heart rate. In relation to nerve recordings, we observed similar values in terms of mean, frequency and amplitude between the groups. In addition, we noted that spontaneous and induced BR control of lumbar sympathetic activity in the LP group was similar to the control group. The data indicate that hypertension in the adult rat offspring subjected to perinatal protein malnutrition is not related to baroreflex dysfunction.

References

Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
Aug 1, 1991·Circulation·A MallianiS Cerutti
Jul 1, 1991·Physiological Reviews·R Hainsworth
Jan 1, 1990·Progress in Neurobiology·M KumadaT Kuwaki
Feb 1, 1970·The American Journal of Physiology·R HainsworthF Carswell
Mar 1, 1993·Current Opinion in Nephrology and Hypertension·J M Wyss
May 1, 1997·The Journal of Nutrition·P G Reeves
May 18, 1999·The American Journal of Physiology·L RudasD L Eckberg
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H C SouzaH C Salgado
Feb 15, 2002·Nutritional Neuroscience·F C TropiaDeoclécio A Chianca
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·R A L DampneyT Tagawa
Mar 17, 2004·The Journal of Physiology·Kenju MikiMisa Yoshimoto
Sep 25, 2004·Nutrition Reviews·Ana Lydia SawayaTelma T Florêncio
Sep 16, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roy KanbarClaude Julien
Feb 20, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Alberto PortaTomaso Gnecchi-Ruscone
Jul 11, 2007·Hypertension·David J P BarkerJohan G Eriksson
Sep 8, 2007·Life Sciences·Igor de O LossDeoclécio A Chianca
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·Claude Julien
Aug 19, 2008·Neuroscience and Biobehavioral Reviews·Nicola MontanoFerdinando Iellamo
Mar 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert K GoldmanVirginia L Brooks
Nov 11, 2009·Hypertension·Anne-Maj SamuelssonPaul D Taylor
Jun 21, 2011·Current Problems in Pediatric and Adolescent Health Care·Kara Calkins, Sherin U Devaskar
Dec 8, 2011·Arquivos brasileiros de cardiologia·Ana Paula Grotti ClementeAna Lydia Sawaya
Aug 25, 2012·Brain Research·Míriam Carmo Rodrigues-BarbosaDeoclécio A Chianca
Sep 22, 2015·Frontiers in Physiology·Fernanda C SilvaDeoclécio A Chianca

Citations

Sep 10, 2016·Clinical and Experimental Pharmacology & Physiology·José Luiz de Brito AlvesJoão Henrique Costa-Silva
Nov 23, 2017·Clinical and Experimental Pharmacology & Physiology·José Luiz de Brito Alves, João Henrique Costa-Silva
Jan 11, 2018·Journal of Developmental Origins of Health and Disease·M MohanyS Alwasel
Dec 2, 2016·Frontiers in Physiology·João Henrique Costa-SilvaMariana P Fernandes
Jul 13, 2018·Frontiers in Physiology·Emily J CammAmanda N Sferruzzi-Perri
Sep 23, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Viviane NogueiraJoão Henrique Costa-Silva
Dec 15, 2019·Metabolism: Clinical and Experimental·Júlia Cristina FacchiJúlio Cezar de Oliveira

Related Concepts

Related Feeds

Cardiovascular Risk Reduction

Prevention of cardiovascular disease is an important health initiative. Risk reduction including physical activity, smoking cessation, diet, blood pressure lowering drugs and pharmacotherapy. Here is the latest research on cardiovascular risk reduction.