Hypertension in Thyroid Disorders

Frontiers in Endocrinology
Eszter BertaMiklós Bodor

Abstract

Arterial hypertension represents a major global health concern; more than one fourth of the population is affected by high blood pressure. Albeit the underlying cause of the disease remains unclear in the vast majority of the cases, ~10% are of secondary origin. Endocrine disorders are common illnesses and some of them may lead to elevated blood pressure, among which thyroid diseases are of high prevalence and often overlooked, especially in mild cases. Overt and subclinical hyper- and hypothyroidism can both lead to (mostly mild) hypertension; however, the underlying mechanisms are only partially understood. The results of clinical studies are often controversial. During the past decades, some genetic mutations in the hypothalamus-pituitary-thyroid axis with cardiovascular consequences were revealed. Atherosclerotic changes resulting from lipid abnormalities due to thyroid dysfunction also affect the vasculature and can cause elevated blood pressure. The review gives a synopsis of our knowledge how thyroid hormone metabolism and functional thyroid diseases affect the cardiovascular system, their negative impact and causative role in the development of hypertension.

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Citations

Jun 4, 2020·Therapeutic Advances in Endocrinology and Metabolism·Patrícia de Fátima Dos Santos TeixeiraCarmen Cabanelas Pazos-Moura
Sep 13, 2020·Science Advances·Milton PividoriHae K Im
Oct 21, 2020·Current Hypertension Reports·Taniya de SilvaDaniel S Hsia
Dec 31, 2020·The Journal of Clinical Hypertension·Stanislovas S JankauskasGaetano Santulli
Sep 25, 2020·Journal of Affective Disorders·Kamila Landucci BonifácioMichael Maes
Dec 5, 2020·Case Reports in Endocrinology·Narangoda Liyanage Ajantha Shyamali, Chandrike Ponnamperuma
Feb 27, 2021·International Journal of Cancer. Journal International Du Cancer·Mohammad Taher ParadSima Afrashteh
Apr 17, 2021·International Journal of Endocrinology·Sanjay KalraDeepak Khandelwal
Nov 14, 2020·Current Pharmaceutical Design·Eleni P KotanidouAssimina Galli-Tsinopoulou

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Methods Mentioned

BETA
hormone replacement therapy

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