Hypertension, Microvascular Pathology, and Prognosis After an Acute Myocardial Infarction

Hypertension
David CarrickColin Berry

Abstract

The rationale for our study was to investigate the pathophysiology of microvascular injury in patients with acute ST-segment-elevation myocardial infarction in relation to a history of hypertension. We undertook a cohort study using invasive and noninvasive measures of microvascular injury, cardiac magnetic resonance imaging at 2 days and 6 months, and assessed health outcomes in the longer term. Three hundred twenty-four patients with acute myocardial infarction (mean age, 59 [12] years; blood pressure, 135 [25] / 79 [14] mm Hg; 237 [73%] male, 105 [32%] with antecedent hypertension) were prospectively enrolled during emergency percutaneous coronary intervention. Compared with patients without antecedent hypertension, patients with hypertension were older (63 [12] years versus 57 [11] years; P<0.001) and a lower proportion were cigarette smokers (52 [50%] versus 144 [66%]; P=0.007). Coronary blood flow, microvascular resistance within the culprit artery, infarct pathologies, inflammation (C-reactive protein and interleukin-6) were not associated with hypertension. Compared with patients without antecedent hypertension, patients with hypertension had less improvement in left ventricular ejection fraction at 6 months from baseli...Continue Reading

References

Mar 25, 1992·Journal of the American College of Cardiology·J E BrushT J Ryan
Apr 4, 1985·The New England Journal of Medicine·UNKNOWN TIMI Study Group
Jan 26, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter KellmanAnthony H Aletras
Mar 30, 2002·Journal of the American College of Cardiology·A Mark RichardsJohn Turner
Aug 15, 2006·Journal of the American College of Cardiology·Ilke SipahiSteven E Nissen
Feb 2, 2008·Journal of the American College of Cardiology·William F FearonAlan C Yeung
Jun 26, 2009·PLoS Medicine·Naveed SattarUNKNOWN Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) Study Group
Jan 1, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Shivraman GiriOrlando P Simonetti
Mar 19, 2011·JACC. Cardiovascular Imaging·David VerhaertSubha V Raman
Aug 28, 2012·European Heart Journal·UNKNOWN Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)Doron Zahger
Aug 28, 2012·Circulation·Kristian ThygesenShanti Mendis
Nov 7, 2012·Journal of the American Heart Association·Alexander R PayneKeith G Oldroyd
Oct 10, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Christopher M KramerUNKNOWN Society for Cardiovascular Magnetic Resonance Board of Trustees Task Force on Standardized Protocols
Aug 12, 2016·Journal of Hypertension·Nils LehmannUNKNOWN Heinz Nixdorf Recall Study Investigators
Nov 12, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Sebastian J ReinstadlerIngo Eitel
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee

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Citations

Nov 12, 2019·Cardiovascular Research·Lara S F KonijnenbergNiels van Royen
Aug 1, 2020·Frontiers in Physiology·Kaihao WangAnthony Martin Gerdes
Dec 16, 2020·ESC Heart Failure·Dominik JenčaPeter Wohlfahrt
Feb 25, 2021·Current Cardiology Reports·Daniel J DohertyColin Berry
Mar 6, 2021·Journal of the American Heart Association·Alan J MoutonJohn E Hall
May 30, 2021·QJM : Monthly Journal of the Association of Physicians·Trina Priscilla NgChing-Hui Sia

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Methods Mentioned

BETA
X-ray
enzyme-linked immunosorbent assay

Clinical Trials Mentioned

NCT02072850

Software Mentioned

R
SAS

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