Hypertension optimal treatment (HOT) study: home blood pressure in treated hypertensive subjects

Hypertension
S E KjeldsenL Hansson

Abstract

The Hypertension Optimal Treatment Study is a prospective trial conducted in 26 countries. The aims are to (1) evaluate the relationship between three levels of target office diastolic blood pressure (BP) (< or = 80, < or = 85, or < or = 90 mm Hg) and cardiovascular morbidity and mortality in hypertensive patients and (2) examine the effects on cardiovascular morbidity and mortality of 75 mg aspirin daily versus placebo. A total of 19,193 patients between 50 and 80 years of age had been randomized by the end of April 1994. Treatment was initiated with felodipine 5 mg daily, and additional therapy was given in accordance with a set protocol. The present substudy of 926 patients performed in nine countries aimed to (1) compare home with office BP in a representative subsample of the HOT population after the titration of treatment was completed and (2) clarify whether the separation into the target groups could be expanded into the out-of-office setting. The differences between office and home measurements in diastolic BP of 0.2 mm Hg (SD, 9; 95% confidence interval, -0.36 to 0.81; P=.40) and systolic BP of 0.5 mm Hg (SD, 15; 95% confidence interval, -0.53 to 1.46; P=.21) were not significant. The group differences in home BP were...Continue Reading

References

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Citations

Feb 23, 2010·Journal of General Internal Medicine·Alan J ChristensenGary E Rosenthal
Apr 12, 2011·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Bonnie J WakefieldGary E Rosenthal
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Jul 23, 2019·Hypertension·Sverre E Kjeldsen, Ingrid Os
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