PMID: 6991408Mar 1, 1980Paper

Hypertension produced by sodium depletion and unilateral nephrectomy: a new experimental model

Hypertension
A A SeymourG M Williams

Abstract

Unilateral nephrectomy of sodium-restricted male Sprague-Dawley rats produced a sustained elevation in systolic blood pressure (SBP) that was reversed by sodium repletion. A chronic intraperitoneal infuson of SQ14,225 prevented the development of hypertension in sodium-deplete unilaterally nephrectomized rats. Sodium depletion of two-kidney rats increased SBP to a lesser extent, while unilateral nephrectomy of sodium replete animals had no effect. These results provide evidence for a new model of experimental hypertension in the rat and emphasize the importance of a renal component, as demonstrated by unilateral nephrectomy, in the maintenance of normal pressure-volume relationships.

References

Jan 1, 1976·Physiological Reviews·J O Davis, R H Freeman
Nov 1, 1972·Journal of Applied Physiology·J Möhring, B Möhring
Nov 1, 1971·The American Journal of Physiology·L Peters-Haefeli

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Citations

Sep 14, 1987·Life Sciences·B WaeberH R Brunner
Dec 8, 1984·Lancet·J J BrownJ H Laragh
Oct 13, 1984·Lancet
Aug 25, 1984·Lancet·J J BrownJ H Laragh
Jan 1, 1984·Experimental Pathology·C Fleck, H Bräunlich
Sep 1, 1986·The Proceedings of the Nutrition Society·A F Lever
Aug 18, 2005·Kidney International·Valentina VanegasBernardo Rodríguez-Iturbe
Oct 1, 1987·Kidney International·J I Robertson
Dec 4, 2009·Translational Oncology·Yi SuiJuliana Cn Chan
Dec 1, 1982·Bioscience Reports·J D Swales
Oct 13, 1984·British Medical Journal·C J Carr

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