Hypertension promotes coronary calcium deposit in asymptomatic men

Hypertension
J L MegnienJ Levenson

Abstract

Despite its important role in coronary disease, coronary atherosclerosis has been poorly investigated in uncomplicated hypertension. Therefore, we evaluated the presence and amount (score) of coronary calcium with ultrafast computed tomography in 73 pairs of age-matched asymptomatic hypertensive or normotensive men. We also estimated the extent of peripheral atherosclerosis as the number of arterial sites (carotid, aortic, femoral) with echographic plaque. Compared with normotensive men, hypertensive men had more frequent coronary calcium (63% versus 47%), a higher calcium score (57 +/- 111 versus 18 +/- 38), and an odds ratio of calcium deposit of 1.95 (with confidence intervals [CI] 95%, 1.01 to 3.79) for any score and of 2.38 (95% CI, 1.02 to 5.52) or 4.84 (95% CI, 1.53 to 15.3) for scores above 50 or 100, respectively. Hypertensive men showed correlations of calcium score with age and hypertension duration but not with the height of blood pressure, and the odds ratio of calcium deposit between extensive and minor peripheral atherosclerosis was 4.67 (95% CI, 1.41 to 15.45) for any score and 8.63 (95% CI, 2.10 to 35.5) or 8.13 (95% CI, 1.64 to 40.3) for scores above 50 or 100. Thus, high blood pressure and in particular its d...Continue Reading

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Citations

May 10, 2005·The American Journal of Cardiology·R Curtis EllisonJ Jeffrey Carr
Sep 2, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Katarzyna Mizia-StecZbigniew Gasior
Apr 18, 2003·Seminars in Roentgenology·Lawrence F BielakPatrick F Sheedy
Oct 29, 2002·Ultrasound in Medicine & Biology·Marco RossiGino Santoro
Feb 20, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lior TolkinNurith Hiller
Feb 5, 2014·American Journal of Ophthalmology·Sucharita BodduR Theodore Smith
Mar 29, 2008·The International Journal of Cardiovascular Imaging·Lars HusmannPhilipp A Kaufmann
Feb 1, 2005·European Journal of Epidemiology·Rozemarijn Vliegenthart
Jun 1, 1997·Kidney International·G M London, T B Drueke
May 12, 2009·The Medical Clinics of North America·Brian P MurphyFrancis G Dunn
Oct 23, 2015·Journal of the American Society of Hypertension : JASH·Sagar Mallikethi-ReddyRobert D Brook
Jul 15, 2015·European Journal of Clinical Investigation·Markus TölleMarkus van der Giet
Feb 6, 2013·American Journal of Hypertension·Chagai GrossmanEhud Grossman
Feb 12, 2004·The Journal of Clinical Hypertension·Alexandros TsakirisP Skoufas
Jul 31, 1998·American Journal of Hypertension·A SimonJ Levenson

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