Hypertension risk in idiopathic hyperCKemia.

Journal of Neurology
Lizzy M BrewsterMarianne de Visser

Abstract

Patients with idiopathic hyperCKemia are usually reassured and discharged. However, these subjects may have increased hypertension risk, based on data from our population study, which showed that the population tertile with the highest serum creatine kinase activities had the highest systolic and diastolic blood pressure levels. Therefore, we assessed whether subjects with idiopathic hyperCKemia have greater occurrence of hypertension than controls. We included 46 participants aged 18 to 67 years, diagnosed with idiopathic hyperCKemia at the departments of Neurology of the Universities of Amsterdam and Utrecht, The Netherlands. We found that 48% of the subjects with idiopathic hyperCKemia were hypertensive, as compared to 19% of the random population controls (n = 22,612, aged 20 to 65 years), an odds ratio of 3.9 (95 % CI, 2.2 to 6.9) before, and 2.0 (1.1 to 3.8) after adjustment for sex, age, and body mass index. In accord with our previous finding of an association between creatine kinase and blood pressure in the general population, the data reported here suggest that subjects with idiopathic hyperCKemia have greater hypertension risk than controls. This may be due to relatively high tissue creatine kinase activity, resulti...Continue Reading

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Citations

Jun 7, 2015·American Journal of Hypertension·Zhila TaherzadehLizzy M Brewster
Jul 10, 2012·Neurologia i neurochirurgia polska·Biruta Kierdaszuk, Anna Kamińska
Jul 31, 2008·The Journal of Clinical Hypertension·Lizzy M Brewster, Gert A van Montfrans
Oct 16, 2013·Hypertension·Fares A KaramatLizzy M Brewster
Aug 10, 2017·Circulation. Cardiovascular Genetics·Moneeza Kalhan SiddiquiUNKNOWN PREDICTION-ADR Consortium
Apr 12, 2019·Medical Sciences : Open Access Journal·L M BrewsterG A van Montfrans
Jun 1, 2010·American Journal of Physiology. Heart and Circulatory Physiology·L M BrewsterG A van Montfrans
Mar 8, 2013·Journal of Hypertension·Inge OudmanLizzy M Brewster
Jun 24, 2020·Purinergic Signalling·L M Brewster
Nov 20, 2019·Journal of Clinical Neuromuscular Disease·Josef FinstererCarla A Scorza
Jul 1, 2020·Hypertension·Lizzy M BrewsterGert A van Montfrans

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