Hypertensive diabetic cardiomyopathy in the rat: ultrastructural features

Virchows Archiv. A, Pathological Anatomy and Histopathology
Stephen M FactorE H Sonnenblick

Abstract

We previously described a cohort of diabetic patients with typical congestive cardiomyopathy, in whom myocardial lesions were related to concomitant high blood pressure. To evaluate the association of diabetes mellitus and hypertension in more detail, we studied 4 groups of rats with either no disease, streptozotocin-induced diabetes mellitus, renovascular hypertension, or a combination of hypertension and diabetes. Analysis revealed significant myocardial fibrosis and degeneration in the hypertensive-diabetic group when compared to controls, without an obvious relationship to small vessel lesions. The myocardial alterations appeared similar to those observed in patients with hypertension and diabetes mellitus. Of note, although hypertensive animals had focal moderate lesions, diabetic animals had no pathological changes. To further characterize these histological changes, we performed electron microscopy on the 4 animal groups, which we are reporting in this study. Our analysis of the ultrastructural alterations confirms the previous histological observations. Diabetic animals only had increased cellular lipid, and mild, focal areas of myofibrillolysis, with no significant increases in perivascular and perisarcolemmal basal la...Continue Reading

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Citations

Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y C HsiaoT Toyota
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