Hypertensive disorders of pregnancy and subsequent maternal cardiovascular health

European Journal of Epidemiology
Nienke E BergenEric A P Steegers

Abstract

To examine associations between hypertensive pregnancy disorders and maternal cardiovascular disease (CVD) in later life. We examined the associations between blood pressure (BP) in pregnancy, gestational hypertension (GH) and preeclampsia (PE) with cardiovascular measurements 6 years after index pregnancy among 4912 women participating in the Generation R Study, the Netherlands. BP, left ventricular mass (LV mass), aortic root diameter (AOD), left atrial diameter, fractional shortening, and carotid-femoral pulse wave velocity (PWV). Early pregnancy systolic and diastolic BP were associated with more adverse maternal cardiovascular measurements and a higher incidence of chronic hypertension 6 years after pregnancy. GH was associated with a higher BP, a higher PWV, a larger AOD and an increased LV mass 6 years after index pregnancy. Compared to previous normotensive pregnancies these women had a sixfold increased risk to develop chronic hypertension after pregnancy (OR 6.6, 95% CI 4.6-9.5). Compared to women with a normotensive pregnancy, women with PE had a higher BP and a higher risk of chronic hypertension (OR 4.5, 95% CI 2.6-7.8) at follow-up. After adjustment for BMI at follow-up in all the analyses on GH, PE and cardiovasc...Continue Reading

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Citations

Dec 7, 2019·Obstetrics and Gynecology·Jose Alberto Martínez-HortelanoVicente Martínez-Vizcaíno
May 31, 2020·BMC Pregnancy and Childbirth·Maria C AdankSarah Schalekamp-Timmermans
May 6, 2020·European Journal of Epidemiology·M Arfan IkramTrudy Voortman
Jun 27, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Anish KeepanasserilAjith A Pillai
May 1, 2020·Frontiers in Cardiovascular Medicine·Karen MelchiorreAsma Khalil
Nov 11, 2020·Journal of the American Heart Association·Mark A BrownGregory K Davis
Dec 16, 2020·American Journal of Perinatology·Logan C BarrGraeme N Smith
Dec 29, 2020·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Xiumei HongCheryl A Winkler
Nov 16, 2021·Frontiers in Cardiovascular Medicine·Guan WangJie Du

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Software Mentioned

Statistical Package for the Social Sciences
metafor
R
rmeta

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