Hypertensive disorders of pregnancy and peripartum cardiomyopathy: A nationwide cohort study

PloS One
Ida BehrensHeather A Boyd

Abstract

Peripartum cardiomyopathy (PPCM) is a serious cardiac disorder occurring late in pregnancy or early in the postpartum period. We examined associations between hypertensive disorders of pregnancy (HDP: preeclampsia and gestational hypertension) and PPCM, accounting for other pregnancy-related risk factors for PPCM. Using nationwide Danish register data, we constructed a cohort of all women with ≥1 live birth or stillbirth in Denmark between 1978 and 2012. Using log-linear binomial regression and generalized estimating equations, we estimated risk ratios (RRs) for PPCM associated with HDP of varying severity. In a cohort of 1,088,063 women with 2,078,822 eligible pregnancies, 126 women developed PPCM (39 in connection with an HDP-complicated pregnancy). The risks of PPCM were significantly higher in women with HDP-complicated pregnancies than in women with normotensive pregnancies (severe preeclampsia, RR 21.2, 95% confidence interval [CI] 12.0-37.4; moderate preeclampsia, RR 10.2, 95% CI 6.18-16.9; gestational hypertension, RR 5.16, 95% CI 2.11-12.6). The RRs for moderate preeclampsia and gestational hypertension were not significantly different from one another (p = 0.18); the RR for severe preeclampsia was significantly differ...Continue Reading

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Citations

Jun 9, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rachel G SinkeyAlan T Tita
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Oct 13, 2019·Cardiovascular Research·Melanie Ricke-HochDenise Hilfiker-Kleiner
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Jan 4, 2021·Journal of Cardiac Failure·Erika J DouglassDelisa Fairweather
Oct 3, 2020·Journal of the American College of Cardiology·Christopher W IvesSuzanne Oparil
Jun 3, 2021·Current Treatment Options in Cardiovascular Medicine·Henrietta A AfariAmy A Sarma
Jul 30, 2021·European Heart Journal·Karen SliwaDenise Hilfiker-Kleiner
Jun 12, 2021·European Journal of Heart Failure·Alice M JacksonUNKNOWN PPCM Investigators Group
Jun 9, 2020·American Journal of Perinatology·Seo-Ho ChoSuzan L Carmichael

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