Hypertensive leg ulcers: epidemiological characteristics and prognostic factors for healing in a prospective cohort

Annales de dermatologie et de vénéréologie
Patricia SenetAngio-dermatologie de la SFD

Abstract

The data concerning changes in the characteristics of hypertensive leg ulcers (HLU) were taken from open studies in a small patient cohort. The aim of this study was to describe the epidemiological characteristics and to identify prognostic factors for healing in a prospective cohort of 59 patients presenting HLU. The cohort comprised patients included in a randomized, double-blind, controlled study published elsewhere; the patients were receiving becaplermin gel (Regranex(®)) or Duoderm Hydrogel™ once daily for eight weeks for the most recent wound. Total follow-up was 12 weeks. The epidemiological analysis was performed for 59 consecutive patients randomized in 17 dermatology departments. Mean patient age was 74.5 ± 9 years and 61% were female. Mean wound duration was 11.1 ± 9 weeks and median wound area was 16 cm(2) (q1; q3: 8; 25.5). Among, 94.9% of patients had hypertension and 39.7% were diabetic. A homolateral peripheral pulse was present in 91.5% of patients. At the end of follow-up, complete wound healing was obtained in 30.5% of the patients. In univariate analysis, neither the foregoing criteria nor the treatment group were significantly associated with healing during the study. This study confirms female predominanc...Continue Reading

References

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Citations

May 15, 2012·Annales de dermatologie et de vénéréologie·G Lorette
Aug 16, 2015·Annales de dermatologie et de vénéréologie·C Lok
Mar 27, 2013·Phlebology·F Pannier, E Rabe
Mar 17, 2019·Rheumatology·Laura FertittaLaure Frumholtz
Mar 13, 2014·International Wound Journal·Alessandro ApollonioUNKNOWN SUV Study Group
Nov 16, 2012·Advances in Skin & Wound Care·Afsaneh AlaviR Gary Sibbald
Jun 7, 2019·Journal of Wound Care·Kirsi IsoherranenMar Llamas Velasco

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