Hypertensive response to stress: the role of histaminergic H1 and H2 receptors in the medial amygdala

Physiology & Behavior
Daniela Oliveira de AlmeidaJosmara Bartolomei Fregoneze

Abstract

Different brain areas seem to be involved in the cardiovascular responses to stress. The medial amygdala (MeA) has been shown to participate in cardiovascular control, and acute stress activates the MeA to a greater extent than any of the other amygdaloid structures. It has been demonstrated that the brain histaminergic system may be involved in behavioral, autonomic and neuroendocrine responses to stressful situations. The aim of the present study was to investigate the role of the histaminergic receptors H1 and H2 in cardiovascular responses to acute restraint stress. Wistar rats (280-320g) received bilateral injections of cimetidine, mepyramine or saline into the MeA and were submitted to 45min of restraint stress. Mepyramine microinjections at doses of 200, 100 and 50nmol promoted a dose-dependent blockade of the hypertensive response induced by the restraint stress. Cimetidine (200 and 100nmol) promoted a partial blockade of the hypertensive response to stress only at the highest dose administered. Neither drugs altered the typical stress-evoked tachycardiac responses. Furthermore, mepyramine and cimetidine were unable to modify the mean arterial pressure or heart rate of freely moving rats under basal conditions (non-stre...Continue Reading

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Citations

Oct 30, 2016·Physiology & Behavior·Brent Myers
Feb 18, 2021·Cellular and Molecular Neurobiology·Christopher L SoudersChristopher J Martyniuk
May 2, 2021·Physiological Reports·Anastasia V SudarikovaDaria V Ilatovskaya
Sep 16, 2018·Neuroscience Letters·Evelyn M GuilhermeAnna C Gianlorenço

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