Hyperthermia and acidification stimulate mechano-growth factor synthesis in murine myoblasts and myotubes

Biochemical and Biophysical Research Communications
Irina V KravchenkoVladimir O Popov

Abstract

The effect of cellular stress factors, the hyperthermia and the acidification of culture medium, on mechano-growth factor (MGF) synthesis by murine myoblasts in culture was investigated. Hyperthermia was shown to stimulate MGF expression both in primary myoblasts and in differentiated multinuclear myotubes. The induction of MGF synthesis peaked at 40 degrees capital ES, Cyrillic, with some activation at 39 and 41 degrees capital ES, Cyrillic. Decrease of culture medium pH stimulated MGF expression with a maximum at pH 6.3. Hydrocortisone eliminated induction of MGF synthesis completely both under hyperthermia and acidification conditions.

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Citations

Aug 26, 2014·Molecular and Cellular Endocrinology·Irina V KravchenkoVladimir O Popov
May 25, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Zhongquan DaiYinghui Li
Nov 18, 2009·Muscle & Nerve·Chengyuan Feng, Christopher S Von Bartheld
Dec 25, 2009·Endocrinology·Miriam van Dijk-OttensMaria E Everts
Dec 14, 2011·Molecular and Cellular Biochemistry·Irina V KravchenkoVladimir O Popov
May 15, 2020·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Egor M LednevDaniil V Popov
Jan 5, 2011·Archives of Biochemistry and Biophysics·Irina V KravchenkoVladimir O Popov

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