PMID: 3693983Nov 1, 1987Paper

Hyperthermia as an adjuvant to radiotherapy in the treatment of malignant melanoma

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
J Overgaard, M Overgaard

Abstract

One hundred and fifteen cutaneous or lymph node metastases from malignant melanoma were treated with three fractions of irradiation alone in 8 days (62 tumours) or followed by heat either immediately (simultaneous treatment, 26 tumours) or after an interval of 3-4 h (sequential therapy, 27 tumours). In addition, three tumours were treated unsuccessfully with heat alone. The total doses of radiation varied between 15 and 30 Gy, allowing a dose-response analysis. For irradiation alone the isoeffective dose to obtain 50 per cent complete response (TCD50) was 26.3 Gy. Addition of heat reduced the TCD50 significantly (p less than 0.05) with a thermal enhancement ratio (TER) of 1.43 for simultaneous treatment and 1.24 for sequential therapy. Also the persistent local control at 18 months was improved by hyperthermia (56 per cent versus 86 per cent, p less than 0.05). However, simultaneous treatment also enhanced the acute skin response to the same extent as the tumour (TER 1.42 for severe erythema). This schedule thus gave no therapeutic gain. In contrast, no normal tissue enhancement was found after sequential treatment (TER 1.02). Such a treatment schedule resulted in a significantly improved therapeutic ratio of 1.22. This effect ...Continue Reading

References

Jun 1, 1979·Cancer Treatment Reviews·S B Field, N M Bleehen
Jun 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J Overgaard
Jan 1, 1986·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·E LeonardiF Piscioli
Apr 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·R ValdagniC Valdagni
Mar 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J OvergaardH von der Maase
Apr 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·H S Reinhold, B Endrich
Apr 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D S Kapp
Apr 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M D Sapozink
Apr 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M W Dewhirst, D A Sim
Jan 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·P R DunlopS B Field
Jun 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D Gonzalez GonzalezP Rümke
Jul 1, 1985·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·G ArcangeliF Mauro
Jul 1, 1985·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M W DewhirstE Bicknell
Dec 1, 1981·Cancer Treatment Reviews·A R Harwood, B J Cummings
Jan 15, 1983·Cancer·C R JohansonI Quirt
Nov 1, 1983·Cancer·C A PerezD VonGerichten
Nov 1, 1983·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J Overgaard, O S Nielsen
Jan 1, 1984·IEEE Transactions on Bio-medical Engineering·J B AndersenJ Overgaard
Sep 1, 1983·International Journal of Radiation Oncology, Biology, Physics·R S ScottL Clay
Jun 1, 1981·International Journal of Radiation Oncology, Biology, Physics·C A PerezJ Mann
Jan 1, 1981·Cancer·A B MillerA Winkler

❮ Previous
Next ❯

Citations

Jun 1, 1994·Journal of Surgical Oncology·G E TurK Koyama
Jan 1, 1992·Biotherapy·C Vernon
Dec 1, 1988·Cell Calcium·T E Nelson
Aug 1, 1996·Controlled Clinical Trials·K Engin
Sep 11, 1999·American Journal of Ophthalmology·D G GodfreyA Capone
Dec 1, 1996·The Surgical Clinics of North America·F B Geara, K K Ang
Feb 11, 1998·International Journal of Radiation Oncology, Biology, Physics·H K LeeM A Lockett
Jan 12, 1994·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·C KnorrH Geldermann
Mar 1, 1997·The British Journal of Ophthalmology·J G Journée-de KorverH Kemme
Aug 10, 2013·Medical Physics·David SchlesingerJames Larner
Nov 1, 1995·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·D S Greenstein, G S Rogers
Dec 21, 2005·International Ophthalmology Clinics·Thomas M Aaberg
May 1, 1995·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·C E LindholmS Hill
Jan 1, 1996·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J OvergaardS M Bentzen
Sep 21, 2010·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J Van Der ZeeG C Van Rhoon
Aug 8, 2006·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J van der ZeeG C van Rhoon
Sep 1, 1990·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·R Valdagni
Jul 1, 1992·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·R A SteevesB R Paliwal
Sep 1, 1992·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J C Lindegaard
Nov 1, 1992·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·C Marino, A Cividalli
Mar 1, 1993·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K Hynynen, K L Davis
Nov 1, 1993·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·R Ben-Yosef, D S Kapp
Jan 1, 1991·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·B Ahmed
Aug 12, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J OvergaardS M Bentzen
Aug 7, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·H Petra KokJohannes Crezee
Feb 12, 2010·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·H Petra KokJohannes Crezee
Sep 1, 1990·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K HynynenR B Roemer
Jan 1, 1995·Acta Oncologica·O Dahl, J Overgaard
Oct 1, 1996·Ophthalmology·C L ShieldsS Kheterpal
Dec 1, 1990·International Journal of Radiation Oncology, Biology, Physics·D S KappM A Bagshaw
Dec 1, 1988·International Journal of Radiation Oncology, Biology, Physics·J van der ZeeM P Broekmeyer-Reurink
Jul 1, 1991·International Journal of Radiation Oncology, Biology, Physics·D L DenmanB S Aron
Apr 1, 1991·International Journal of Radiation Oncology, Biology, Physics·L Roizin-Towle, J P Pirro
Jan 1, 1993·International Journal of Radiation Oncology, Biology, Physics·K EnginD B Leeper
Nov 1, 1991·International Journal of Radiation Oncology, Biology, Physics·G ArcangeliL Begnozzi
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·H S MaoJ Overgaard
Oct 1, 2005·Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering·L SunN B Smith
Jun 1, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Annette PflugfelderUNKNOWN German Society of Dermatology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
D Gonzalez GonzalezP Rümke
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
C A PerezB Fineberg
Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer
C E LindholmB Persson
British Journal of Anaesthesia
J S SullivanM A Denborough
© 2021 Meta ULC. All rights reserved