Hyperthermia associated with drug intoxication

Critical Care Medicine
J RosenbergK Olson

Abstract

Hyperthermia (temperature of at least 40.5 degrees C for at least one hour) associated with drug intoxication was identified in 12 patients over a 5-yr period. Intoxication was due to anticholinergic drugs (tricyclic antidepressants, antipsychotics, antihistamines), CNS stimulants (phencyclidine, cocaine, 3,4-methylene dioxyamphetamine, mescaline, lysergic acid diethylamide), salicylates, or combinations of these. Hyperthermia was present in four patients on admission, but its onset was delayed up to 12 h in the remainder. Outcome of hyperthermic patients was poor: five died and four had severe permanent neurologic sequelae. Clinical signs common to patients who developed hyperthermia were increased muscular activity and absence of sweating. Five patients suffered seizures, and four did not respond to anticonvulsant medication until body temperature was lowered. Cooling did not appear to favorably affect the outcome after body temperature had remained above 40.5 degrees C for a prolonged period. Prevention of death or neurologic sequelae from drug-induced hyperthermia depends upon the recognition of risk factors and the prompt treatment of hyperthermia.

Citations

Dec 12, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Josef G ThundiyilKent R Olson
Oct 23, 1997·Critical Care Clinics·T C ChanR F Clark
Jan 9, 1993·BMJ : British Medical Journal·B Tehan
Feb 20, 1993·BMJ : British Medical Journal·P S Ramrakha, I Barton
Apr 24, 2004·Anesthesia and Analgesia·Chun-Ming LinAndrea Kurz
May 1, 1996·Intensive Care Medicine·P HantsonF J Baud
Jan 1, 1996·Journal of Toxicology. Clinical Toxicology·F G WalterN L Benowitz
Mar 19, 2014·Disease-a-month : DM·Michael E NelsonSteven E Aks
Nov 28, 2013·Emergency Medicine Clinics of North America·Michael E NelsonSteven E Aks
Sep 8, 2011·Chest·Michael LevineAnne-Michelle Ruha
May 27, 2008·Pediatric Clinics of North America·Cheryl L CramerLucian K DeNicola
Jul 1, 1994·Annals of Emergency Medicine·C W Callaway, R F Clark
Aug 1, 1989·Anaesthesia·P R Wood, N Soni
Sep 22, 2007·Human & Experimental Toxicology·Hiroshi KinoshitaShigeru Hishida
Feb 27, 2018·Current Hypertension Reports·Andrew KingLuke Bisoski
Sep 11, 2018·The American Journal of Forensic Medicine and Pathology·Angélique FranchiLaurent Martrille
Dec 1, 1993·The British Journal of Surgery·N E Beck, J E Hale
Jan 26, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·William P Cheshire, Robert D Fealey
Jul 24, 2008·Anesthesiology·Daniel I Sessler
Aug 28, 2013·The Journal of Pharmacology and Experimental Therapeutics·Nicholas J Connors, Robert S Hoffman
Apr 7, 2020·Experimental Physiology·Caroline S WestwoodJoseph D Layden
Nov 2, 1989·The New England Journal of Medicine·A W Fox
Oct 1, 2014·Temperature : Multidisciplinary Biomedical Journal·Christine K DaoEdward M Mills
Jan 9, 1993·BMJ : British Medical Journal·U Ravnskov
Jan 29, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Stanley N CaroffHenry Rosenberg
Sep 24, 2021·Neurotoxicity Research·Jan van AmsterdamWim van den Brink

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved