Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy.

Advanced Drug Delivery Reviews
Michael DunneChristine Allen

Abstract

Hyperthermia has demonstrated clinical success in improving the efficacy of both chemo- and radio-therapy in solid tumors. Pre-clinical and clinical research studies have demonstrated that targeted hyperthermia can increase tumor blood flow and increase the perfused fraction of the tumor in a temperature and time dependent manner. Changes in tumor blood circulation can produce significant physiological changes including enhanced vascular permeability, increased oxygenation, decreased interstitial fluid pressure, and reestablishment of normal physiological pH conditions. These alterations in tumor physiology can positively impact both small molecule and nanomedicine chemotherapy accumulation and distribution within the tumor, as well as the fraction of the tumor susceptible to radiation therapy. Hyperthermia can trigger drug release from thermosensitive formulations and further improve the accumulation, distribution, and efficacy of chemotherapy.

Citations

Oct 1, 2020·Biomaterials Science·Tongyi ShangBin Yang
Mar 9, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Javier Mancilla-Galindo, Norma Galindo-Sevilla
Aug 2, 2021·Advanced Drug Delivery Reviews·Nisi ZhangKatherine W Ferrara
Oct 1, 2021·Drug Development and Industrial Pharmacy·Bakhshali MassoumiMehdi Jaymand

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