Hyperthermia generated by magnetic nanoparticles for effective treatment of disseminated peritoneal cancer in an orthotopic nude-mouse model.

Cell Cycle
Yuki MatsumiHiroyuki Kishimoto

Abstract

Magnetic hyperthermia (MHT), which combines magnetic nanoparticles (MNPs) with an alternating magnetic field (AMF), holds promise as a cancer therapy. There have been many studies about hyperthermia, most of which have been performed by direct injection of MNPs into tumor tissues. However, there have been no reports of treating peritoneal disseminated disease with MHT to date. In the present study, we treated peritoneal metastasis of gastric cancer with MHT using superparamagnetic iron oxide (Fe3O4) nanoparticle (SPION) coated with carboxydextran as an MNP, in an orthotopic mouse model mimicking early peritoneal disseminated disease of gastric cancer. SPIONs of an optimal size were intraperitoneally administered, and an AMF (390 kHz, 28 kAm-1) was applied for 10 minutes, four times every three days. Three weeks after the first MHT treatment, the peritoneal metastases were significantly inhibited compared with the AMF-alone group or the untreated-control group. The results of the present study show that MHT can be applied as a new treatment option for disseminated peritoneal gastric cancer.Abbreviations: AMF: alternating magnetic field; Cy1: cytology-positive; DMEM: Dulbecco's Modified Eagle's Medium; FBS: fetal bovine serum; H&...Continue Reading

References

Jan 1, 1984·IEEE Transactions on Bio-medical Engineering·P R StaufferR B Roemer
Jul 1, 1994·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·N IkedaT Matsuda
Oct 1, 1957·Annals of Surgery·R K GILCHRISTC B TAYLOR
Mar 24, 2011·Future Medicinal Chemistry·Sophie LaurentRobert N Muller
Sep 30, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Neena G ShetakeBadri N Pandey
Feb 3, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiuyang LiuYan Li
Jun 6, 2017·Trends in Immunology·Selene Meza-Perez, Troy D Randall
Jul 22, 2017·Current Gastroenterology Reports·Maya BalakrishnanDavid Y Graham
Sep 6, 2017·Journal of the Neurological Sciences·Carmela RinaldiAntonina Sidoti

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