PMID: 2498937Jan 1, 1989Paper

Hyperthermia induced by m-CPP in the rat and its modification by antidepressant treatments

Psychopharmacology
K M WozniakD L Murphy

Abstract

Administration of the serotonin agonist m-chlorophenylpiperazine to rats produced a dose-related hyperthermia. Pretreatment with the serotonin receptor antagonist metergoline totally abolished this response, whereas similar treatment with haloperidol, phenoxybenzamine, naloxone, clonidine, pindolol, propranolol, methiotepin, and ritanserin was ineffective. In studies investigating the modification of the response by antidepressant treatments both acute (3 day) and chronic (22 day) administration of the MAO inhibitor clorgyline, as well as the tricyclics clomipramine and imipramine, attenuated the hyperthermic response to m-CPP. These findings are discussed with regard to the specificity of m-CPP-induced hyperthermia and its subsequent modification by antidepressant treatments, in order to evaluate this model's use as a probe for assessment of the serotonergic system.

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Citations

Dec 1, 1991·Biological Psychiatry·R S Kahn, S Wetzler
Nov 1, 1994·Pharmacology, Biochemistry, and Behavior·C S AulakhD L Murphy
Dec 1, 1991·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·G VolterraA Lecci
Jan 1, 1990·Annals of the New York Academy of Sciences·D L Murphy
Nov 27, 2004·The Journal of Pharmacy and Pharmacology·Aska HayashiKeiji Miyata
May 26, 2004·Brain Research·Aska HayashiKeiji Miyata
Mar 19, 2014·Neuroscience and Biobehavioral Reviews·Cedric B P MartinRaymond Mongeau
Apr 1, 1992·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·M CantinM Gottschalk
Jul 2, 2011·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·María LópezCarmen Torres
Dec 13, 2019·Pharmacological Reviews·Henry SzechtmanKurt Leroy Hoffman
Mar 1, 1994·Neuropharmacology·F G Boess, I L Martin

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