Hyperthermia induces apoptosis by targeting Survivin in esophageal cancer

Oncology Reports
Sida QinHong Ren

Abstract

Hyperthermia is considered the fifth pillar of cancer treatment. It induces cancer cell apoptosis, however, its molecular mechanisms remain unclear. In the present study, the role of Survivin in hyperthermia-induced apoptosis in esophageal cancer was investigated. Different temperatures were used to treat EC109 esophageal cancer cells, and their viability was found to be significantly inhibited with a concomitant increase in apoptosis and necrosis. Necrosis increased in a temperature‑dependent manner, whereas peak apoptosis was reached at 43˚C. The hyperthermia-induced apoptosis was due to the inhibition of Survivin and the activation of caspase-3. Subsequently, overexpression of Survivin inhibited the activation of caspase-3 and hyperthermia-induced apoptosis, however, this inhibition was reversed in the absence of XIAP. Immunoprecipitations showed that Survivin did not directly bind to caspase-3, whereas XIAP interacted with Survivin and caspase-3. Immunohistochemistry was performed to detect the expression of Survivin in esophageal cancer patient samples. A higher expression of Survivin in esophageal cancer tissues compared to normal tissues was observed, and a high expression correlated with poor prognosis. The results indi...Continue Reading

References

Jun 26, 2004·The Journal of Biological Chemistry·Takehiko DohiDario C Altieri
Dec 14, 2007·Nature Reviews. Cancer·Dario C Altieri
Mar 20, 2008·Expert Opinion on Therapeutic Targets·Marzia PennatiNadia Zaffaroni
Jun 30, 2009·Cancer Treatment Reviews·Bríd M RyanMichael J Duffy
Nov 3, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Denis C TalbotPatricia Price
Jan 25, 2011·Journal of Surgical Oncology·Tad KimSteven N Hochwald
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Aug 23, 2011·Recent Patents on Anti-cancer Drug Discovery·Paula I P SoaresJoao P M R Borges
Jun 1, 2012·The New England Journal of Medicine·P van HagenUNKNOWN CROSS Group
Jun 13, 2012·Medicinal Research Reviews·Jagat R KanwarRupinder K Kanwar
Sep 14, 2012·Langenbeck's Archives of Surgery·Florian LordickChristian Wittekind
Mar 5, 2013·Cancer Treatment Reviews·Mohane Selvaraj CoumarChun Hei Antonio Cheung
Apr 10, 2013·General Thoracic and Cardiovascular Surgery·Hiroyuki Kato, Masanobu Nakajima
Sep 17, 2013·World Journal of Gastroenterology : WJG·Yuwei Zhang
Oct 23, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Alicia A PetrykP Jack Hoopes
Oct 26, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Sabrina T HeijkoopAnneke M Westermann
Feb 4, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naoki KanekoSadao Kuromitsu
Feb 18, 2014·International Journal of Molecular Sciences·Mahsa MobahatKarl Riabowol
May 9, 2014·The Lancet Oncology·Adam Januszewski, Justin Stebbing
Jun 12, 2014·Journal of Cancer Research and Clinical Oncology·Hidekazu KoikeKazuhiro Suzuki
Jul 30, 2014·Nature Chemical Biology·Georg E WinterGiulio Superti-Furga
Jul 30, 2014·Molecular Medicine Reports·Yvonne Y Y OrRoberta W C Pang
Sep 10, 2014·Oncology Letters·Gennaro Gadaleta-CaldarolaCosmo Damiano Gadaleta

❮ Previous
Next ❯

Citations

Oct 16, 2016·Journal of Experimental & Clinical Cancer Research : CR·Chengcheng YangSida Qin
Aug 9, 2016·International Journal of Oncology·Sida QinHong Ren
Jun 21, 2019·Analytical Cellular Pathology (Amsterdam)·Peng HuangYan-Qiao Zhang
Jul 29, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sida QinHong Ren
Mar 17, 2021·Phytotherapy Research : PTR·Yijia ZengJilin Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis