Hyperthermia of the cancerous breast: analysis of mechanism

Cancer Letters
M Anbar

Abstract

Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe2+, which catalyses the formation of NO. NO, in turn, releases Fe2+ from ferritin. This mechanism implies: (1) dependence of hyperthermia on the ferritin content of the neoplastic tissue; (2) oscillatory behavior of the hyperperfusion; (3) hyperthermia that extends far beyond the boundaries of the neoplastic tissue; (4) diminished neurological control of the perfusion in the affected breast; (5) limitations on the observed asymmetry between the breasts. These five effects were previously observed in numerous independent studies. Monitoring the temporal behavior of the hyperthermia is expected to substantially increase both sensitivity and specificity of cancer detection.

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Citations

Jun 14, 1995·Experientia·M Anbar
Nov 5, 1997·Journal of Pain and Symptom Management·M Anbar, B M Gratt
Dec 24, 2002·Annals of the New York Academy of Sciences·Michael Anbar
Dec 20, 2002·AJR. American Journal of Roentgenology·Y R PariskyK Callahan
Oct 16, 2015·Medical & Biological Engineering & Computing·Asnida Abd WahabKhin Wee Lai
Jun 2, 2000·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·J R KeyserlingkM Yassa
Jun 2, 2000·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·M AnbarL Gentner
Oct 24, 2001·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·M AnbarK AlDulaimi
Mar 5, 2015·Medical Physics·Michal Tepper, Israel Gannot
Sep 27, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Barton M Gratt, Michael Anbar
Jul 22, 1998·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·M Anbar
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Feb 14, 2008·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Qi ZhaoWei Cong
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