PMID: 376463Apr 1, 1979Paper

Hyperthermic inactivation of diploid yeast and the interaction of damage caused by hyperthermia and ionizing radiation

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
M S MurthyB S Rao

Abstract

Inactivation of diploid yeast by hyperthermia has been studied. DO and Dq decrease with temperature for euoxic and anoxic conditions. The Arrhenius plot shows a break at 52 degrees C; the inactivation energies above and below this temperature are 153 and 94kcal/mol respectively. Hyperthermia (20 min at 51 degrees C) also potentiates the lethal action of gamma rays in diploid yeast cells under both euoxic and anoxic conditions. The interaction between hyperthermic and radiation damage appears to be largely at the sublethal level. The euoxic cells, the hyperthermic potentiation decreases with increasing time between the application of hyperthermia and radiation, being completely lost after 24 hours. However, in the anoxic cells there was no decrease in the hyperthermic potentiation with increasing time interval. These results suggest that yeast cells are capable of repairing hyperthermic sublethal damage, but require oxygen to do so. Thus there is a similarity in the process of repair of sublethal damage caused by ionizing radiation on the one hand and hyperthermia on the other.

Citations

Jul 1, 1991·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·B S RaoV V Deorukhakar
Jan 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C Z Chen, D E Watt
Mar 1, 1981·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·V G Petin, I P Berdnikova
Sep 1, 1981·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·N M ReddyU Madhvanath
Sep 27, 2014·Biochimica Et Biophysica Acta·Avinash AppukuttanYury Ladilov
Dec 19, 2003·Radiation Research·Vladislav G Petin, Jin Kyu Kim
May 13, 2004·Photochemistry and Photobiology·Jin Kyu KimMarianna D Tkhabisimova

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