Hyperthermic intraperitoneal chemotherapy in ovarian cancer: first report of the HYPER-O registry

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Cyril William HelmShesh N Rai

Abstract

An analysis of experience of surgical and gynecologic oncologists in the United States with the use of hyperthermic intraperitoneal chemotherapy for women with invasive epithelial ovarian cancer (EOC). An Internet-based registry (HYPER-O) collected data from collaborating institutions. Eligibility included women with EOC treated with hyperthermic intraperitoneal chemotherapy. Borderline and nonepithelial cancers were excluded. As of July 1, 2008, 141 women were eligible for analysis treated at the following time points: frontline (n = 26), interval debulking (n = 19), consolidation (n = 12), and recurrence (n = 83). The mean perfusion temperatures were 38.5 to 43.6 degrees C (median, 41.9 degrees C) for inflow and 36.9 to 42.9 degrees C (median, 41 degrees C) for outflow for 30 to 120 minutes. Treatment was with a platinum agent (n = 72), mitomycin (n = 53), or a combination (n = 14). Median follow-up was 18 months (range, 0.3-140.5 months) and median overall survival 30.3 months (95% confidence interval, 23.0-37.6) with 2-, 5-, and 10-year overall survival probabilities of 49.1%, 25.4%, and 14.3%, respectively. Of the 141 patients, 110 (78%) experienced recurrence of ovarian cancer and 87 died, 3 (0.5%) dying within 30 days of...Continue Reading

References

Mar 11, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MarkmanJ L Lewis
Nov 1, 1989·British Journal of Cancer·M E GoreA H Calvert
Sep 4, 1995·International Journal of Cancer. Journal International Du Cancer·J HavemanP J Bakker
Jan 1, 1997·Journal of Cancer Research and Clinical Oncology·R C RietbroekC H Veenhof
Jun 13, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P J van de VaartA C Begg
Jan 6, 2000·Annals of Surgical Oncology·P H Sugarbaker, D Chang
May 4, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A J WitkampF A Zoetmulder
Jun 25, 2002·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M Urano, C C Ling
Jul 13, 2002·Expert Review of Anticancer Therapy·M Markman
Mar 8, 2003·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M TakemotoY Hiraki
May 8, 2003·Annals of Surgical Oncology·Faheez MohamedPaul H Sugarbaker
Feb 7, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M LookP H Sugarbaker
Oct 20, 2004·Gynecologic Oncology·A R Munkarah, R L Coleman
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Apr 22, 2005·Journal of Surgical Oncology·Trevor W ReichmanLawrence E Harrison
Jan 6, 2006·The New England Journal of Medicine·Deborah K ArmstrongUNKNOWN Gynecologic Oncology Group
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C W HelmR P Edwards
Oct 22, 2008·Gynecologic Oncology·Robert E BristowDennis S Chi

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Citations

Aug 14, 2012·Gastroenterology Research and Practice·Evgenia HalkiaPaul Sugarbaker
Mar 18, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Karol PolomFranco Roviello
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Lieselotte LemoineKurt Van der Speeten
Oct 30, 2013·Journal of Surgical Oncology·Kaitlyn J Kelly, Garrett M Nash
Oct 26, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Krishnansu S Tewari
Oct 2, 2013·Annals of Surgical Oncology·Maryann Kwa, Franco Muggia
Jan 10, 2013·Investigational New Drugs·Mazin F Al-KasspoolesKatherine F Roby
Nov 20, 2013·Langenbeck's Archives of Surgery·Yakup KuluAlexis Ulrich
Dec 18, 2013·Current Treatment Options in Oncology·Ramez N EskanderRobert E Bristow
Jun 4, 2020·Expert Opinion on Pharmacotherapy·Eelco de Bree, Dimosthenis Michelakis
Aug 1, 2012·Expert Review of Anticancer Therapy·Eelco de Bree, C William Helm
Apr 12, 2016·Indian Journal of Surgical Oncology·Aditi Bhatt, Olivier Glehen
Apr 12, 2016·Indian Journal of Surgical Oncology·Aditi BhattPaul H Sugarbaker
Feb 20, 2021·Seminars in Cancer Biology·Marco PetrilloVito Chiantera
Jun 27, 2020·Journal of Gynecology Obstetrics and Human Reproduction·Anthony B CostalesRobert Debernardo
Aug 30, 2014·Journal of Visceral Surgery·N BakrinO Glehen

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