Hypertonic saline resuscitation prevents hydrostatically induced intestinal edema and ileus.

Critical Care Medicine
Ravi S RadhakrishnanCharles S Cox

Abstract

We have shown that acute edema induced by mesenteric venous hypertension (MV-HTN) impairs intestinal transit and reduces the standardized engineering measures of intestinal stiffness (elastic modulus) and residual stress (opening angle). We hypothesized that hypertonic saline (7.5%) would reverse these detrimental effects of acute edema. Laboratory study. University laboratory. Male Sprague Dawley rats (270-330 g). Rats were randomized to five groups: sham, MV-HTN alone, MV-HTN with 4 mL/kg normal saline resuscitation (equal volume), MV-HTN with 33 mL/kg normal saline resuscitation (equal salt), and MV-HTN with 4 mL/kg hypertonic saline. Intestinal edema was measured by wet to dry tissue weight ratio. A duodenal catheter was placed and, 30 mins before death, fluorescein isothiocyanate Dextran was injected. At death, dye concentrations were measured to determine intestinal transit. Segments of distal ileum were hung to a fixed point in a tissue bath and to a force displacement transducer and stretched in increments of 1 mm; we recorded the new length and the corresponding force from the force displacement transducer to determine elastic modulus. Next, two transverse cuts were made yielding a 1- to 2-mm thick ring-shaped segment ...Continue Reading

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Citations

Mar 12, 2010·The Journal of Trauma·Shinil K ShahCharles S Cox
May 11, 2010·The Journal of Trauma·Joseph J DuBosePeter Rhee
Jan 30, 2016·Journal of Veterinary Emergency and Critical Care·KimMi WhiteheadLaura Eirmann
Dec 5, 2009·The Journal of Surgical Research·Shinil K ShahCharles S Cox
Dec 13, 2006·The Journal of Surgical Research·Ravi S RadhakrishnanCharles S Cox
Jul 2, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S K ShahC S Cox
Jan 9, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Elaheh RahbarDavid C Zawieja
Oct 20, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Silvia MarchesiGöran Hedenstierna
Dec 19, 2018·The Journal of Trauma and Acute Care Surgery·Tyler J LoftusScott C Brakenridge
Nov 16, 2017·The Journal of Trauma and Acute Care Surgery·Tyler J LoftusScott C Brakenridge
Feb 6, 2019·Mathematical Medicine and Biology : a Journal of the IMA·Travis B ThompsonMatthew G Knepley
Apr 1, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Ketaki V DesaiUwe M Fischer
Jan 29, 2013·The Journal of Trauma and Acute Care Surgery·John A HarvinBryan A Cotton
Dec 1, 2020·Frontiers in Veterinary Science·Randolph H Stewart

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