PMID: 2480072Dec 1, 1989Paper

Hypertonic saline solution-hetastarch for fluid resuscitation in experimental septic shock.

Anesthesia and Analgesia
C W Armistead Thuc Le Minh

Abstract

Hypertonic colloid solutions have been found efficacious in the resuscitation from hemorrhagic/traumatic shock. The present study investigated the hemodynamic, gasometric, and metabolic effects of hypertonic colloids in endotoxic shock in the dog. Thirty minutes after administration of 3 mg/kg normal body weight of Escherichia coli endotoxin, dogs were randomly assigned to receive 10 mL/kg hydroxyethylstarch (HES) either in 0.9% NaCl (HES, 10 dogs) or in 7.5% NaCl (HT-HES, 10 dogs) in 30 min. Thereafter, 0.9% NaCl solution was administered in volumes adequate to maintain pulmonary artery balloon-occluded pressure at baseline levels. Total fluid administered averaged 64 +/- 30 mL/kg (mean +/- SD) in the HES group and 73 +/- 34 mL/kg in the HT-HES group. As these differences were not statistically significant, total sodium load was higher in the HT-HES group. The persistent volume effect was associated with persistently lower hematocrit and protein levels in the HT-HES group. Initial fluid resuscitation with HT-HES resulted in arterial pressure, cardiac filling pressures, cardiac output, stroke volume, and rates of oxygen delivery and oxygen consumption that were greater than those with HES. Vascular resistances were similar. Ana...Continue Reading

Citations

Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Claudio Esteves LagoaMaurício Rocha e Silva
Jan 26, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·N LibertG Mion
Apr 1, 1991·The Annals of Thoracic Surgery·J BoldtG Hempelmann
Nov 1, 1995·São Paulo Medical Journal = Revista Paulista De Medicina·A Monteiro PachecoK Messmer
Jun 6, 2006·Journal of the Royal Army Medical Corps·R Thompson, I Greaves
Jan 31, 2006·Journal of the Royal Army Medical Corps·R C C Thompson
Dec 17, 2008·Critical Care Nursing Quarterly·Anil SinghPeter D Kaplan

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