Hypertonic saline treatment of acid aspiration-induced lung injury

The Journal of Surgical Research
R RabinoviciL F Neville

Abstract

Airway acid aspiration leads to severe microvascular lung injury and pulmonary edema. Recent studies have demonstrated that other conditions associated with microvascular injury such as sepsis and burns can be effectively treated with low-volume hypertonic saline (HTS). Thus, the present study aimed to test whether HTS attenuates aspiration-induced lung injury in the rat. Intratracheal administration of 0.2 ml of 0.1 N HCl (n = 7) induced pulmonary leukosequestration [myeloperoxidase (MPO) activity +446 +/- 34%, P < 0.05; bronchoalveolar lavage (BAL) fluid neutrophil count + 178 +/- 23%, P < 0.05], edema (division 43 +/- 6%, P < 0.01), and microvascular permeability defect (BAL protein concentration +675 +/- 34%, P < 0.01). These changes were associated with tissue hypoxia (skeletal muscle PO2, 49 +/- 8 mm Hg, P < 0.05) and elevated serum TNF alpha (750 +/- 38 pg/ml, P < 0.01). HTS (2400 mosmole/liter) at 5 ml/kg, administered 20 min after aspiration (n = 7), reduced lung pulmonary edema by 58 +/- 7% (P < 0.05) and improved tissue oxygen tension (PO2, 85 +/- 7 mm Hg, P < 0.05) but failed to alter lung MPO and BAL fluid protein and leukocyte count response. Also, HTS did not reduce TNF alpha response to aspiration. These data po...Continue Reading

Citations

Mar 10, 2016·Respiratory Physiology & Neurobiology·Shailesh BihariAndrew D Bersten
Apr 22, 2006·ANZ Journal of Surgery·Alexios A AdamidesJeffrey V Rosenfeld
May 25, 2006·Surgical Neurology·Sheng-Jean HuangYong-Kwang Tu
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Apr 19, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shailesh BihariAndrew Bersten
Jul 27, 2021·Frontiers in Veterinary Science·Armi Pigott, Elke Rudloff
Jul 6, 2021·Intensive Care Medicine Experimental·Shailesh BihariAndrew D Bersten

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