Hypertonic Saline Versus Isotonic Saline Nasal Irrigation: Systematic Review and Meta-analysis

American Journal of Rhinology & Allergy
Dichapong KanjanawaseeK Snidvongs

Abstract

Background Saline nasal lavage is one of the treatments of sinonasal diseases. Evidence from basic research favors hypertonic saline (HS) over isotonic saline (IS) for mucociliary clearance, but evidence from clinical studies is controversial. Conversely, HS may carry greater side effects. Objective To compare the effects of HS and IS nasal irrigation in treating sinonasal diseases. Methods Systematic search with Ovid MEDLINE, Scopus, PubMed, Google Scholar, and Manual additional sources was conducted. Randomized controlled trials comparing HS with IS nasal irrigation in treating any sinonasal diseases, including rhinitis and rhinosinusitis, were included. Data were pooled for meta-analyses. Outcomes were symptom scores, sinonasal outcome test (SNOT), and adverse events. Heterogeneity was explored by subgroup analyses. Results Nine studies (740 patients) were included. HS nasal irrigation brought greater benefits over IS in symptom reduction (standardized mean difference (SMD) -0.58; 95% confidence interval [CI]: -0.76, -0.40); however, no difference was shown in SNOT-20 improvement (mean difference 1.81; 95% CI: -0.68, 4.30). In subgroup analyses, effects favoring HS on symptoms were larger in 4 subgroups. These were (1) patie...Continue Reading

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Jul 31, 2018·American Journal of Rhinology & Allergy·Harshita Pant
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Feb 14, 2021·Pharmaceutics·Junhu TaiTae Hoon Kim
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May 8, 2021·International Forum of Allergy & Rhinology·Wirach ChitsuthipakornKornkiat Snidvongs
Jan 1, 2022·International Forum of Allergy & Rhinology·Wirach ChitsuthipakornKornkiat Snidvongs

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