PMID: 15691463Feb 5, 2005

Hypertransaminasemia greater than 400 U/l in adults seen at a tertiary hospital. Prospective study of etiology

Gastroenterología y hepatología
M BrugueraA Mas


To investigate the frequency of distinct causes of elevated transaminase levels in the range of acute viral hepatitides in patients attended in a hospital. Patients attended in a tertiary hospital over a 3-month period who had elevation of transaminase levels (aspartate aminotransferase [AST] or alanine aminotransferase [ALT]) above 400 U/l were identified and their medical records were reviewed to determine etiology. A total of 106 patients were studied, of which 22 had undergone liver transplantation. In these patients, the causes of hypertransaminasemia were ischemic/reperfusion injury in 6 (27%), ischemic hepatitis in 4 (18%), acute hepatitis in 2 (9%), cellular rejection in 3 (14%), chronic hepatitis C in 4 (18%) and cholestasis in 3 (14%). In the 84 patients who did not undergo transplantation, the causes were hepatic ischemia in 24 (28%), chronic viral hepatitis in 19 (22%), toxic hepatitis in 12 (14%), pancreatico-biliary disease in 11 (13%), acute viral or bacterial hepatitis in 10 (12%), liver tumor in 3 (4%), cholestasis of pregnancy in one and unknown in 4 (5%). Ischemic lesions and pancreatico-biliary disease were more frequent in hospitalized patients while acute and chronic hepatitides were more frequent in outpa...Continue Reading


Sep 7, 2005·Journal of Gastroenterology·Akira Matsui
Apr 14, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Danny ConJohn S Lubel
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Jean Henrion
Aug 26, 2017·World Journal of Hepatology·Pik-Eu ChangChee-Kiat Tan

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