Hypertriglyceridaemia and the risk of pancreatitis six months post lopinavir/ritonavir initiation

Southern African Journal of HIV Medicine
Wilhelm P GreffrathMarike Cockeran

Abstract

Hypertriglyceridaemia (HTG) is an important risk factor for pancreatitis and cardiovascular disease (CVD), depending on severity. Hypertriglyceridaemia is common in human immunodeficiency virus (HIV) infection and is also a common complication of lopinavir/ritonavir (LPV/r). To evaluate the risk of pancreatitis associated with HTG in patients six months post initiation of LPV/r-based therapy in a regional public hospital. Triglyceride (TG), serum amylase (s-amylase) and CD4+ count values were retrospectively investigated six months post LPV/r-based initiation. Age, gender, previous antiretroviral regimen and period since HIV diagnosis were also recorded. The final sample consisted of 194 patients, 50 males and 144 females; mean (± standard deviation [s.d.]) age was 39.52 (± 9.98) years, and the mean (± s.d.) period since HIV diagnosis was 91.32 (± 25.18) months. Normal TG levels (< 1.70 mmol/L) were detected in only 55% of patients and the rest presented with some degree of HTG. The mean (± s.d.) TG for the entire sample was elevated at 1.94 (± 1.30) mmol/L with the mean (± s.d.) of the males at 2.36 (± 1.74) - statistically higher compared to the females at 1.79 (± 1.08) mmol/L (p = 0.034). No cases of pancreatitis were record...Continue Reading

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Citations

Jun 5, 2020·Journal of Medical Virology·Giuseppe BrunoGiovanni B Buccoliero
Jul 25, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dragana JavoracAleksandra Buha Djordjevic
Aug 28, 2021·World Journal of Clinical Cases·Bo ZhaoRui Zheng

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