Hypertriglyceridemia and cardiovascular risk: a cautionary note about metabolic confounding.

Journal of Lipid Research
Allan D SnidermanGeorge Thanassoulis

Abstract

Triglycerides are the conventional tool to measure VLDLs, whereas LDL cholesterol (LDL-C) is the conventional tool to measure LDLs. Multiple epidemiological studies, including a series of genetically based analyses, have demonstrated that cardiovascular risk is related to triglycerides independently of LDL-C, and this has led to a series of new therapeutic agents designed specifically to reduce plasma triglycerides. The triglyceride hypothesis posits that increased levels of triglycerides increase cardiovascular risk and decreasing plasma triglycerides decreases cardiovascular risk. In this work, we will examine the validity of the triglyceride hypothesis by detailing the biological complexities associated with hypertriglyceridemia, the genetic epidemiological evidence in favor of hypertriglyceridemia, the evidence from the fibrate randomized clinical trials relating triglycerides and clinical outcomes, and the completeness of the evidence from the initial studies of novel mutations and the therapeutic agents based on these mutations that lower triglycerides. Because of the multiple metabolic links between VLDL and LDL, we will try to demonstrate that measuring triglycerides and LDL-C alone are inadequate to document the lipopr...Continue Reading

References

Jan 2, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·P N DurringtonM Hartog
Jan 27, 1975·JAMA : the Journal of the American Medical Association
Mar 1, 1976·Metabolism: Clinical and Experimental·J D BrunzellE L Bierman
Dec 1, 1982·Annals of Internal Medicine·A D SnidermanP O Kwiterovich
Jul 6, 2000·Circulation·UNKNOWN Bezafibrate Infarction Prevention (BIP) study
Nov 12, 2009·JAMA : the Journal of the American Medical Association·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
Mar 17, 2010·The New England Journal of Medicine·Henry N GinsbergRobert P Byington
May 11, 2010·Lancet·UNKNOWN Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors CollaborationJohn Danesh
Oct 15, 2010·The New England Journal of Medicine·Kiran MusunuruSekar Kathiresan
Aug 1, 2007·Journal of Clinical Lipidology·Allan SnidermanPatrick Couture
Sep 27, 2012·Journal of Clinical Lipidology·Allan D SnidermanPatrick Couture
Dec 26, 2012·Journal of the American College of Cardiology·Anette VarboBørge G Nordestgaard
Feb 23, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kenta MoriKen-ichi Hirata
May 16, 2013·Journal of the American Heart Association·Carlos O MendivilFrank M Sacks
May 25, 2013·Circulation Research·Murray W Huff, Robert A Hegele
Jan 30, 2014·European Heart Journal·Michael V HolmesJuan P Casas
Apr 22, 2014·Atherosclerosis·Allan D SnidermanPatrick Couture
Jun 19, 2014·The New England Journal of Medicine·Jacy CrosbySekar Kathiresan
Jun 19, 2014·The New England Journal of Medicine·Anders Berg JørgensenAnne Tybjærg-Hansen
Aug 1, 2014·Current Atherosclerosis Reports·Paul N HopkinsM Nazeem Nanjee
Dec 4, 2014·The New England Journal of Medicine·Daniel GaudetJoseph L Witztum
Jun 24, 2015·Current Opinion in Lipidology·David Marais
Jul 30, 2015·The New England Journal of Medicine·Daniel GaudetJohn J P Kastelein
May 7, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Changting XiaoGary F Lewis

❮ Previous
Next ❯

Citations

Jan 30, 2019·JAMA : the Journal of the American Medical Association·Ann Marie Navar
May 8, 2019·European Journal of Preventive Cardiology·Alberto AimoMichele Emdin
May 10, 2019·Circulation Research·Allan D SnidermanGeorge Thanassoulis
Oct 24, 2019·JAMA Cardiology·Allan D SnidermanBrian A Ference
Dec 14, 2018·European Journal of Preventive Cardiology·Angela Pirillo, Alberico Luigi Catapano
Aug 27, 2019·The Journal of Clinical Investigation·Henry N Ginsberg, Gissette Reyes-Soffer
Dec 10, 2020·Phytotherapy Research : PTR·Matteo MicucciAndrea Angeletti
Jan 28, 2021·Journal of Clinical Medicine·Andras BikovStefan Mihaicuta
Dec 17, 2020·Frontiers in Oncology·Jianai SunHong-Hu Zhu
Jan 14, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Massimiliano RuscicaNicola Ferri
Nov 25, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Tamara Glavinovic, Allan D Sniderman
Feb 19, 2021·Global Heart·Kavita SinghDorairaj Prabhakaran
May 11, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ciaran N Kohli-LynchAllan D Sniderman
Jul 8, 2020·Journal of Clinical Lipidology·Martine PaquetteAlexis Baass
May 28, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Hui ZhangZhihong Ye

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.